Topical pharmaceutical compositions for treating skin conditions
First Claim
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1. A topical pharmaceutical composition for treating a skin condition or disorder, comprising:
- an active agent in an amount from 0.01% to 1% by weight of the composition, wherein the active agent consists of tretinoin;
a polymeric emulsifier, wherein the polymeric emulsifier comprises a cross-linked copolymer of acrylic acid and C10-C30 alkyl acrylate, and wherein the polymeric emulsifier is present in an amount from 0.02% to 0.08% by weight of the composition;
a viscosity increasing agent, wherein the viscosity increasing agent comprises a cross-linked homopolymer of an acrylic acid, and wherein the viscosity increasing agent is present in an amount from 0.1% to 2% by weight of the composition;
a moisturizing agent, wherein the moisturizing agent comprises soluble collagen and sodium hyaluronate, and wherein the moisturizing agent is present in an amount from 5% to 10% by weight of the composition;
an oil component comprising one or more oils, wherein the oil component is present in an amount from 1% to 3.5% by weight of the composition, and wherein each oil in the oil component is independently selected from the group consisting of mineral oil, light mineral oil, petrolatum, fatty alcohols, monocarboxylic acid esters, dicarboxylic acid esters, medium-chain triglycerides, and long-chain triglycerides; and
water;
wherein the composition is formulated as a lotion.
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Abstract
In one aspect, topical pharmaceutical compositions for treating a skin condition or disorder are provided. In some embodiments, the topical pharmaceutical composition is formulated as a lotion and comprises a therapeutically effective amount of an active agent; a viscosity increasing agent; a polymeric emulsifier; and an oil component. In some embodiments, the topical pharmaceutical composition comprises tretinoin.
12 Citations
21 Claims
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1. A topical pharmaceutical composition for treating a skin condition or disorder, comprising:
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an active agent in an amount from 0.01% to 1% by weight of the composition, wherein the active agent consists of tretinoin; a polymeric emulsifier, wherein the polymeric emulsifier comprises a cross-linked copolymer of acrylic acid and C10-C30 alkyl acrylate, and wherein the polymeric emulsifier is present in an amount from 0.02% to 0.08% by weight of the composition; a viscosity increasing agent, wherein the viscosity increasing agent comprises a cross-linked homopolymer of an acrylic acid, and wherein the viscosity increasing agent is present in an amount from 0.1% to 2% by weight of the composition; a moisturizing agent, wherein the moisturizing agent comprises soluble collagen and sodium hyaluronate, and wherein the moisturizing agent is present in an amount from 5% to 10% by weight of the composition; an oil component comprising one or more oils, wherein the oil component is present in an amount from 1% to 3.5% by weight of the composition, and wherein each oil in the oil component is independently selected from the group consisting of mineral oil, light mineral oil, petrolatum, fatty alcohols, monocarboxylic acid esters, dicarboxylic acid esters, medium-chain triglycerides, and long-chain triglycerides; and water; wherein the composition is formulated as a lotion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A topical pharmaceutical composition for treating a skin condition or disorder, wherein the topical pharmaceutical composition is formulated as a lotion and comprises:
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an active agent an amount of 0.05% by weight of the composition wherein the active agent consists of tretinoin; a carbomer copolymer type B in an amount from 0.04% to 0.06% by weight of the composition; a carbomer homopolymer type A in an amount from 0.2% to 1% by weight of the composition; soluble collagen and sodium hyaluronate in an amount from 5% to 10% by weight of the composition; an oil component in an amount up to 3.5% by weight of the composition, wherein the oil component consists of mineral oil; one or more preservatives, antioxidants, humectants, wetting agents, and/or neutralizing agents; and water. - View Dependent Claims (21)
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Specification