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Topical pharmaceutical compositions for treating skin conditions

  • US 10,653,656 B2
  • Filed: 08/22/2018
  • Issued: 05/19/2020
  • Est. Priority Date: 04/05/2018
  • Status: Active Grant
First Claim
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1. A topical pharmaceutical composition for treating a skin condition or disorder, comprising:

  • an active agent in an amount from 0.01% to 1% by weight of the composition, wherein the active agent consists of tretinoin;

    a polymeric emulsifier, wherein the polymeric emulsifier comprises a cross-linked copolymer of acrylic acid and C10-C30 alkyl acrylate, and wherein the polymeric emulsifier is present in an amount from 0.02% to 0.08% by weight of the composition;

    a viscosity increasing agent, wherein the viscosity increasing agent comprises a cross-linked homopolymer of an acrylic acid, and wherein the viscosity increasing agent is present in an amount from 0.1% to 2% by weight of the composition;

    a moisturizing agent, wherein the moisturizing agent comprises soluble collagen and sodium hyaluronate, and wherein the moisturizing agent is present in an amount from 5% to 10% by weight of the composition;

    an oil component comprising one or more oils, wherein the oil component is present in an amount from 1% to 3.5% by weight of the composition, and wherein each oil in the oil component is independently selected from the group consisting of mineral oil, light mineral oil, petrolatum, fatty alcohols, monocarboxylic acid esters, dicarboxylic acid esters, medium-chain triglycerides, and long-chain triglycerides; and

    water;

    wherein the composition is formulated as a lotion.

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