Magnetic nanoparticle embedded nanofibrous membrane

• US 10,653,818 B2
• Filed: 01/23/2015
• Issued: 05/19/2020
• Est. Priority Date: 01/23/2014
• Status: Active Grant

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Yoon, Yong-Kyu, Fang, Sheng-Po
• Primary Examiner(s): Choi, Peter Y
• Application Number:
  US15/113,633
• Publication Number:
  US 20170239393A1
• Time in Patent Office: 1,943 Days
• Field of Search: 442376
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/042 Iron or iron alloys
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: D01D 5/0007 Electro-spinning non-woven fabrics produced by electro-spinning D04H1/728
• CPC Class Codes: D01D 5/0061 characterised by the electro-spinning apparatus
• CPC Class Codes: D04H 1/728 by electro-spinning electro-spinning methods and apparatus D01D5/0007

Abstract

Various examples are provided for magnetic particle imbedded nanofibrous membranes. In one example, among others, a nanofibrous membrane includes one or more electrospun nanofibers forming form a layer of nanofibers, and a plurality of magnetic nanoparticles embedded in the one or more electrospun nanofibers. In another example, a method includes generating one or more electrospun nanofibers including magnetic nanoparticles from one or more nozzles positioned over a substrate to form a magnetic nanofibrous layer, and affixing the magnetic nanofibrous layer to a support structure. In another example, a system includes a magnetic nanofibrous membrane affixed to a support structure, and a magnetic field generator configured to generate a magnetic field that passes through the magnetic nanofibrous membrane.

Claims

1. A nanofibrous membrane, comprising:

one or more electrospun nanofibers forming a layer of nanofibers affixed to a support structure, the layer of nanofibers extending across an opening of the support structure in a substantially planar orientation and affixed to the support structure along an edge of the opening by a non-toxic glue; and

a plurality of magnetic nanoparticles embedded in the one or more electrospun nanofibers of the layer of nanofibers,

where the layer of nanofibers deflects out-of-plane within the opening of the support structure in response to exposure to a magnetic field passing through the opening of the support structure, where the support structure is a machined printed circuit board (PCB) O-ring with the opening.

2. The nanofibrous membrane of claim 1, wherein the magnetic field is time varying.

3. The nanofibrous membrane of claim 1, wherein the deflection of the layer of nanofibers is controlled by the magnetic field.

4. The nanofibrous membrane of claim 1, wherein the layer of nanofibers is a tissue scaffold.

5. The nanofibrous membrane of claim 4, wherein the layer of nanofibers affixed to the support structure has a resonant frequency of deflection in a range of about 4 Hz to about 5 Hz.

6. The nanofibrous membrane of claim 1, wherein the plurality of magnetic nanoparticles comprise iron oxide nanoparticles.

7. The nanofibrous membrane of claim 1, wherein the one or more electrospun nanofibers comprise a biodegradable polymer.

8. The nanofibrous membrane of claim 7, wherein the one or more electrospun nanofibers comprise polycaprolactone.

9. The nanofibrous membrane of claim 1, wherein the support structure is configured to deliver or detect electrical signals to or from cells on the nanofibrous membrane.

10. The nanofibrous membrane of claim 1, wherein the magnetic field is generated by a magnetic field generator positioned below the nanofibrous membrane.

11. The nanofibrous membrane of claim 10, wherein magnetic flux of the magnetic field is maintained less than 10 Gauss.

12. The nanofibrous membrane of claim 1, wherein variation of the magnetic field produces a mechanical oscillation of the layer of nanofibers affixed to the support structure in a range from about 50 nm to about 240 nm.

13. The nanofibrous membrane of claim 1, wherein the plurality of magnetic nanoparticles are about 5% wt of the one or more electrospun nanofibers.

14. The nanofibrous membrane of claim 1, wherein the plurality of magnetic nanoparticles comprise one or more of nickel, cobalt, or neodymium.

15. The nanofibrous membrane of claim 4, wherein variation of the magnetic field produces a mechanical oscillation of the layer of nanofibers affixed to the support structure that is within 1% of a cell volume size of cells when on the tissue scaffold.

16. The nanofibrous membrane of claim 1, wherein the support structure comprises a first portion and a second portion, and the layer of nanofibers is affixed between the first portion and the second portion of the support structure by the non-toxic glue.