Polyomavirus neutralizing antibodies
First Claim
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1. A pharmaceutical composition comprising an antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof binds to BK virus VP 1 and comprises:
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
6, (b) a HCDR2 of SEQ ID NO;
7, (c) a HCDR3 of SEQ ID NO;
8 and a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
16, (e) a LCDR2 of SEQ ID NO;
17, and (f) a LCDR3 of SEQ ID NO;
18.
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Abstract
The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
12 Citations
21 Claims
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1. A pharmaceutical composition comprising an antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof binds to BK virus VP 1 and comprises:
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
6, (b) a HCDR2 of SEQ ID NO;
7, (c) a HCDR3 of SEQ ID NO;
8 and a light chain variable region that comprises;
(d) a LCDR1 of SEQ ID NO;
16, (e) a LCDR2 of SEQ ID NO;
17, and (f) a LCDR3 of SEQ ID NO;
18. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- a heavy chain variable region that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO;
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21. A pharmaceutical composition, comprising an antibody and a pharmaceutically acceptable carrier, wherein the antibody comprises a heavy chain variable region (vH) that comprises SEQ ID NO:
- 12, and a light chain variable region (vL) that comprises SEQ ID NO;
22, and wherein the pharmaceutically acceptable carrier contains histidine, sucrose, and a polysorbate.
- 12, and a light chain variable region (vL) that comprises SEQ ID NO;
Specification