Windowed sequencing
First Claim
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1. A system comprising:
- a sensor array including a plurality of sensors; and
an array controller, communicatively coupled to the sensor array, wherein the array controller includes a processor, the processor configured to;
determine an operational characteristic of each sensor of a plurality of sensors located at a portion of the sensor array before a chemical reaction occurs proximal to each sensor of the plurality of sensors located at the portion of the sensor array,select a first group of sensors from the plurality of sensors located at the portion of the sensor array based on determining that each sensor in the first group of sensors has a similar operational characteristic,enable readout of the sensors in the first group,bypass readout of other sensors of the sensor array that are not included in the first group of sensors, wherein the other sensors have a different operational characteristic from the first group of sensors, andreceive output signals at the processor from the first group of sensors, the output signals indicating chemical reactions occurring proximate to the first group of sensors of the sensor array.
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Abstract
In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.
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Citations
16 Claims
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1. A system comprising:
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a sensor array including a plurality of sensors; and an array controller, communicatively coupled to the sensor array, wherein the array controller includes a processor, the processor configured to; determine an operational characteristic of each sensor of a plurality of sensors located at a portion of the sensor array before a chemical reaction occurs proximal to each sensor of the plurality of sensors located at the portion of the sensor array, select a first group of sensors from the plurality of sensors located at the portion of the sensor array based on determining that each sensor in the first group of sensors has a similar operational characteristic, enable readout of the sensors in the first group, bypass readout of other sensors of the sensor array that are not included in the first group of sensors, wherein the other sensors have a different operational characteristic from the first group of sensors, and receive output signals at the processor from the first group of sensors, the output signals indicating chemical reactions occurring proximate to the first group of sensors of the sensor array. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for nucleic acid sequencing, comprising:
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an array including a plurality of sensors; and an array controller, communicatively coupled to the array, wherein the array controller includes a processor, the processor configured to; analyze output signals of the sensors of the array in response to template nucleic acids provided to at least some of a plurality of locations coupled to the sensors of the array, wherein the output signals are analyzed to identify which locations in the plurality of locations contain the template nucleic acids and which locations in the plurality of locations do not contain the template nucleic acids, select a first group of sensors from the sensors in the array, wherein sensors in the first group of sensors are selected based on the locations containing the template nucleic acids, enable readout of the sensors in the first group of sensors in the sensor array including the locations containing the template nucleic acids, and and bypass readout of other sensors of the sensor array, wherein the other sensors are in the locations not containing the template nucleic acids, and measure the output signals of the first group of sensors in response to known nucleotides introduced within at least some of the plurality of locations to detect sequencing reaction byproducts resulting from incorporation of the introduced known nucleotides into one or more primers hybridized to at least one of the template nucleic acids, wherein the first group of sensors is selected prior to the reaction between the template nucleic acids and the known nucleotides. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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Specification