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Rare event detection using mass tags

  • US 10,656,157 B2
  • Filed: 09/23/2015
  • Issued: 05/19/2020
  • Est. Priority Date: 09/24/2014
  • Status: Active Grant
First Claim
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1. A method for detecting a target analyte in a sample, the method comprising:

  • conducting an assay that specifically associates a mass tag with a target analyte in a sample;

    depolymerizing the mass tag to generate a plurality of molecules that are dissociated from the target analyte;

    capturing the plurality of molecules via an affinity agent on a spray probe, thereby pre-concentrating the plurality of molecules;

    generating, via the spray probe, a plurality of ions from the plurality of molecules; and

    analyzing the plurality of ions, thereby detecting the target analyte from the sample.

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