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Self-adjusting tissue holder

  • US 10,660,754 B2
  • Filed: 06/18/2018
  • Issued: 05/26/2020
  • Est. Priority Date: 07/23/2014
  • Status: Active Grant
First Claim
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1. A method for gripping a tissue in a tissue holder, the method comprising:

  • associating a first portion of the tissue with a first holding plate of the tissue holder, the first holding plate comprising a first side and a second side, the first portion of the tissue being associated with the second side of the first holding plate, the first holding plate defining a primary opening that passes from the first side of the first holding plate to a second side of the first holding plate;

    aligning a second holding plate with the first holding plate, the second holding plate defining a primary opening that passes from a first side of the second holding plate to a second side of the second holding plate, the primary opening of the second holding plate and the primary opening of the first holding plate being axially aligned upon the alignment, the second side of the first holding plate and the first side of the second holding plate being adjacent to one another with the first portion of the tissue being held between the second side of the first holding plate and the first side of the second holding plate upon the alignment, a second portion of the tissue extending from the first portion that is held between the first and second holding plates and extending across the primary openings;

    tightening a clamping mechanism to apply a clamping force on the tissue first portion that is held between the two holding plates, the clamping force also being applied to a spring that applies a force to either the first holding plate or the second holding plate; and

    decellularizing the tissue as it is held in the tissue holder, wherein a thickness of the tissue first portion changes during the decellularization, the clamping mechanism self-adjusting upon the change in thickness and maintaining the clamping force on the tissue first portion during the decellularization.

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