Seeping flow anti-clotting blood catheter

• US 10,661,050 B2
• Filed: 04/11/2018
• Issued: 05/26/2020
• Est. Priority Date: 01/14/2014
• Status: Active Grant

• Current Assignee: Charles Stark Draper Laboratory Incorporated
• Original Assignee: Charles Stark Draper Laboratory Incorporated
• Inventors: Charest, Joseph L., Hsiao, James, DiBiasio, Christopher, Hufford, Kevin A.
• Primary Examiner(s): Bouchelle, Laura A
• Assistant Examiner(s): Doubrava, John A
• Application Number:
  US15/950,783
• Publication Number:
  US 20180229002A1
• Time in Patent Office: 776 Days
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/006 having a special surface topography or special surface properties, e.g. roughened or knurled surface
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 25/0029 characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports catheter shaft surface irregularities A61M2025/006
• CPC Class Codes: A61M 25/0043 characterised by structural features

Abstract

A catheter includes an elongated tube having a distal end and a proximal end. The elongated tube includes porous material having an interior and an exterior face. The interior face defines a lumen along a central axis of the elongated tube. The porous material is configured to flow a fluid between the interior face and the exterior face and to seep the fluid out of the porous material through the exterior face and interior face. A lining covers at least a portion of the exterior face and substantially limits perfusion through the exterior face at the portion of the exterior face covered by the lining. The catheter is impregnated with a material that prevents buildup of material on one of an inner face or an outer face of the catheter or the lining is coated with one or more of an anticoagulant, antibiotic, or antithrombotic.

Claims

1. A catheter comprising:

an elongated tube having a distal end and a proximal end, the elongated tube comprising a porous material having an interior face and an exterior face, the interior face defining a lumen along a central axis of the elongated tube, the porous material being configured to flow a fluid substantially parallel to the central axis between the interior face and the exterior face of the porous material and to seep the fluid out of the porous material through the exterior face and interior face;

a lining covering at least a portion of the exterior face and substantially limiting a perfusion through the exterior face at the portion of the exterior face covered by the lining;

a fitting coupled to the proximal end of the elongated tube, the fitting configured to flow a first fluid into the porous material and a second fluid into the lumen, the fitting including a collar disposed about a circumference of the catheter and configured to inject the first fluid into the porous material through the exterior face of the porous material; and

one or more of;

the catheter being impregnated with a material that prevents buildup of material on one of an inner face or an outer face of the catheter; and

the lining being coated with one or more of an anticoagulant, antibiotic, or antithrombotic.

2. A system comprising:

a catheter including;

an elongated tube having a distal end and a proximal end, the elongated tube comprising a porous material having an interior face and an exterior face, the interior face defining a lumen along a central axis of the elongated tube, the porous material being configured to flow a fluid substantially parallel to the central axis between the interior face and the exterior face of the porous material and to seep the fluid out of the porous material through the exterior face and interior face;

a lining covering at least a portion of the exterior face and substantially limiting a perfusion through the exterior face at the portion of the exterior face covered by the lining; and

one or more of;

the catheter being impregnated with a material that prevents buildup of material on one of an inner face or an outer face of the catheter; and

the lining being coated with one or more of an anticoagulant, antibiotic, or antithrombotic;

a primary fitting configured to inject a fluid into the lumen of the catheter;

a fluid reservoir including the fluid;

a pump configured to flow the fluid from the fluid reservoir through the primary fitting into the lumen of the catheter;

a controller configured to control the pump;

a secondary fitting configured to inject a second fluid into the porous material;

a second fluid reservoir including the second fluid; and

a second pump configured to flow the second fluid from the second fluid reservoir through the secondary fitting into the porous material, the second pump being controlled by the controller.

3. The system of claim 2, wherein the controller is configured to cause one of the pump and the second pump to flow fluid through the catheter in a pulsatile manner.

4. The system of claim 2, wherein the primary fitting and secondary fitting are located at separate lengths along the catheter.

5. The system of claim 2, wherein the pump is configured to create a vacuum to draw fluid from a patient through the catheter.

6. The system of claim 2, wherein the second fluid includes one or more of a blood thinner, an anti-coagulant, a thrombolytic agent, a medication, an antibiotic, an antiviral, a dye, a label, a tracing substance, a protein, a peptide, DNA, RNA, RNAi, or siRNA, a coagulant, or an agent to reverse (or counteract) one or more of the foregoing agents.

7. The system of claim 2, wherein the second fluid includes one or more of solutions to alter pH, solutions to alter compound concentrations in blood, binding agents to chelate or bind entities in blood, dissolved or other formats of gases, a capture agent to specifically tether/bind/capture an entity in blood, an agent to alter viscosity of a fluid in the lumen, toxin, an agent to counter a toxin, simple saline buffers or fluids, sugars, amino acids fats or other nutritive agents, inert molecules, volume expanders for the fluid in the lumen, or an agent to reverse (or counteract) one or more of the foregoing agents.

8. The system of claim 4, wherein the fluid reservoir and the second fluid reservoir are the same reservoir.

9. The system of claim 4, wherein the controller is configured to pressurize the fluid flowing through the lumen to a different pressure than the second fluid flowing through the porous material.

10. The system of claim 8, wherein the fluid and the second fluid are the same fluid.

11. The system of claim 5, wherein the second pump is configured to inject the second fluid in to the porous material and seep the second fluid out of the porous material while the pump creates the vacuum to draw the fluid from the patient.