Treatment of alzheimer's disease

• US 10,661,099 B2
• Filed: 06/14/2016
• Issued: 05/26/2020
• Est. Priority Date: 06/16/2015
• Status: Active Grant

• Current Assignee: Cartilast II LLC
• Original Assignee: Eugene R. Moore
• Inventors: Moore, Eugene R.
• Primary Examiner(s): Cox, Thaddeus B
• Application Number:
  US14/999,685
• Publication Number:
  US 20160367837A1
• Time in Patent Office: 1,442 Days
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/501 for diagnosis of the head, e.g. neuroimaging or craniography
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI

Abstract

A method for the treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease by treating the patient'"'"'s brain, over the span of one year or less with a plurality of doses of ionizing radiation, each dose being more than 2.5 mJ/kg but less than 150 mJ/kg with the total dose being more than 10 mJ/kg but less than 400 mJ/kg.

Claims

1. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein the treatment is reversing one or more clinical symptoms of Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in the reversal of one or more of the clinical symptoms of Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease.

2. The method of claim 1, wherein the total dose is greater than 20 mJ/kg.

3. The method of claim 1, wherein the total dose is greater than 40 mJ/kg.

4. The method of claim 1, wherein the total dose is greater than 80 mJ/kg.

5. The method of claim 1, wherein the total dose is less than 300 mJ/kg.

6. The method of claim 1, wherein the total dose is less than 180 mJ/kg.

7. The method of claim 1, wherein the plurality of doses of ionizing radiation are a plurality of CT scans.

8. The method of claim 1, wherein the plurality of doses of ionizing radiation are delivered by a megavoltage linear accelerator.

9. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein the plurality of doses of ionizing radiation are delivered by simple x-ray equipment having no imaging capability.

10. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein plurality of doses of ionizing radiation are generated from cobalt 60.

11. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein the plurality of doses of ionizing radiation are generated from spent nuclear fuel.

12. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in morphology of the hippocampus area of the brain as determined by a CT scan image of the hippocampus area of the brain.

13. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in a morphology of the hippocampus area of the brain as determined by an MRI scan of the hippocampus area of the brain.

14. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in blood chemistry markers associated with neurodegenerative disease.

15. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in a morphology of the hippocampus area of the brain as determined by a PET scan of the brain.

16. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in a score of a Folstein Mini-Mental State Examination of the person.

17. A method for a treatment of a person suffering from neurodegenerative disease such as Alzheimer'"'"'s, Parkinson'"'"'s, or Huntington'"'"'s disease, the method comprising:

irradiating the person'"'"'s brain with a plurality of doses of ionizing radiation, each dose being greater than 2.5 mJ/kg but less than 150 mJ/kg for a total dose over a period of time of a year or less being greater than 10 mJ/kg but less than 400 mJ/kg, wherein there is a period of time between the plurality of doses of ionizing radiation, which period of time is determined by measuring a plateau in neuropsychological testing of the person.