Polymer comprising a plurality of phenothiazine groups and methods of making the same

• US 10,662,264 B2
• Filed: 03/08/2018
• Issued: 05/26/2020
• Est. Priority Date: 05/28/2010
• Status: Active Grant

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Inventors: Fei, Jiangfeng, Chiang, William, Kerrigan, Frank, Green, Stuart, Robson, Craig, Easterfield, Howard
• Primary Examiner(s): Truong, Duc
• Application Number:
  US15/915,184
• Publication Number:
  US 20180194877A1
• Time in Patent Office: 810 Days
• Field of Search: 528419
• CPC Class Codes: A61K 49/0004 Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
• CPC Class Codes: C07D 279/08 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 279/20 with hydrogen atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 417/14 containing three or more hetero rings
• CPC Class Codes: C08F 8/30 Introducing nitrogen atoms or nitrogen-containing groups
• CPC Class Codes: C08F 8/34 Introducing sulfur atoms or sulfur-containing groups
• CPC Class Codes: C08G 59/4007 Curing agents not provided for by the groups C08G59/42 - C08G59/66
• CPC Class Codes: C08G 59/4064 sulfur containing compounds C08G59/4021, C08G59/4028 take precedence
• CPC Class Codes: C08G 73/024 Polyamines containing oxygen in the form of ether bonds in the main chain
• CPC Class Codes: C08G 75/24 Polysulfonates
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

Claims

1. An electrochemical test sensor comprising a working electrode, a counter electrode and a mediator, the mediator including a polymer, the polymer including a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone;

where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV);

2. The electrochemical test sensor of claim 1, wherein the phenothiazine group is bonded to the polymeric backbone through a carbon-heteroatom bond.

3. The electrochemical test sensor of claim 1, wherein the phenothiazine group is bonded to the polymeric backbone through a group selected from the group consisting of an ether group, an ester group, a carbonate group, a urea group, a urethane group, an amine group, an amide group, a thioether group, a thiourea group and a sulfonamide group.

4. The electrochemical test sensor of claim 3, wherein the phenothiazine group is bonded to the polymeric backbone through a group selected from an ether group or an ester group.

5. The electrochemical test sensor of claim 3, wherein the phenothiazine group is bonded to the polymeric backbone through a carbonate group.

6. The electrochemical test sensor of claim 3, wherein the phenothiazine group is bonded to the polymeric backbone through a urea group or a urethane group.

7. The electrochemical test sensor of claim 3, wherein the phenothiazine group is bonded to the polymeric backbone through an amine group or an amide group.

8. The electrochemical test sensor of claim 3, wherein the phenothiazine group is bonded to the polymeric backbone through a thioether group or a thiourea group.

9. The electrochemical test sensor of claim 3, wherein the phenothiazine group is bonded to the polymeric backbone through a sulfonamide group.

10. The electrochemical test sensor of claim 1 further including glucose oxidase.

11. The electrochemical test sensor of claim 1 further including glucose dehydrogenase.

12. An electrochemical test sensor comprising a working electrode, a counter electrode, glucose dehydrogenase, and a mediator, the mediator including a polymer, the polymer including a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone;

where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV);

13. An electrochemical test sensor comprising a working electrode, a counter electrode, glucose oxidase, and a mediator, the mediator including a polymer, the polymer including a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone;

where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV);