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Spatially encoded biological assays

  • US 10,662,467 B2
  • Filed: 02/14/2019
  • Issued: 05/26/2020
  • Est. Priority Date: 04/05/2010
  • Status: Active Grant
First Claim
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1. A method of associating presence or abundance of a target biological molecule with a location of a tissue sample, comprising:

  • delivering a plurality of probes to a tissue sample affixed to a support, wherein a probe of the plurality of probes comprises a protein that specifically binds a target biological molecule of the tissue sample, wherein the protein is conjugated to an oligonucleotide having a sequence, andseparating the probe specifically bound to the target biological molecule at the location of the tissue sample from the plurality of probes not specifically bound to the target biological molecule at the location of the tissue sample; and

    sequencing all or a portion of the sequence of the oligonucleotide or a complement thereof, from the specifically bound probe, and using the determined sequence to associate presence or abundance of the target biological molecule with the location of the tissue sample.

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