Intraocular drug delivery

• US 10,667,947 B2
• Filed: 06/02/2017
• Issued: 06/02/2020
• Est. Priority Date: 06/02/2016
• Status: Active Grant

• Current Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Original Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Inventors: Horvath, Christopher, Romoda, Laszlo O.
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US15/613,018
• Publication Number:
  US 20170348150A1
• Time in Patent Office: 1,096 Days
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/222 Gelatin
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

An ab externo method of placing an intraocular implant into an eye can include advancing a needle, in which the implant is disposed, into the eye through conjunctiva and sclera of the eye. The implant can include a drug deliverable to the eye. The implant can thereafter be released to be anchored in the eye and elute the drug to the eye.

Claims

1. An ab externo method of placing an intraocular implant into an eye, the method comprising the steps of:

advancing a needle, in which the implant is disposed, into the eye through conjunctiva, Tenon'"'"'s capsule, and sclera of the eye, the implant comprising a drug deliverable to the eye; and

releasing the intraocular implant to anchor the implant within an intrascleral space of the eye, wherein the implant functions as a plug to obstruct fluid flow from an anterior chamber of the eye toward the intrascleral space upon release.

2. The method of claim 1, wherein when released, a proximal end of the implant is positioned within the sclera.

3. The method of claim 1, wherein the releasing comprises positioning a first portion of the implant within an anterior chamber of the eye and a second portion of the implant within the intrascleral space.

4. The method of claim 1, wherein advancing the needle further comprises advancing a pusher rod within the needle to position the implant at a distal portion of the needle.

5. The method of claim 4, comprising positioning a bevel of the needle within an anterior chamber of the eye while advancing the pusher rod to advance a first portion of the implant through the bevel of the needle while permitting a second portion of the implant to remain within the needle.

6. The method of claim 1, comprising positioning a bevel of the needle within an anterior chamber of the eye.

7. The method of claim 6, wherein the positioning comprises orienting a longitudinal axis of the needle at an angle relative to a visual axis of the eye to facilitate placement of a second portion of the implant deep to a superficial layer of the sclera and a first portion of the implant within the anterior chamber of the eye.

8. The method of claim 1, further comprising the step of contacting a sleeve, coupled to the needle, against an external surface of the eye, to restrict further longitudinal advancement of the needle into the eye.

9. The method of claim 1, comprising positioning a bevel of the needle within a choroidal space of the eye and a first portion of the implant within the choroidal space.

10. The method of claim 1, comprising positioning a bevel of the needle within a vitreous space of the eye and a first portion of the implant within the vitreous space.

11. The method of claim 1, wherein the implant comprises a tapered cross-sectional profile, the releasing comprising anchoring the implant by positioning a larger cross-sectional profile first end portion of the implant superficially within the sclera and a smaller cross-sectional profile second end portion deep to the first end portion.

12. The method of claim 1, wherein the implant is configured to elute the drug therefrom to permit flow from the anterior chamber after obstructing flow therefrom.

22. The method of claim 12, wherein the elution of the drug opens a lumen through the implant.

13. An ab externo method of placing an intraocular implant into an eye, the method comprising the steps of:

advancing a needle, in which the implant is disposed, into the eye through conjunctiva and sclera of the eye, the implant comprising a drug deliverable to the eye, the implant comprising a tapered cross-sectional profile; and

releasing the intraocular implant to anchor the implant within an intrascleral space of the eye by positioning a larger cross-sectional profile first end portion of the implant superficially within the sclera and a smaller cross-sectional profile second end portion deep to the first end portion.

14. The method of claim 13, wherein advancing the needle further comprises advancing a pusher rod within the needle to position the implant at a distal portion of the needle.

15. The method of claim 14, comprising positioning a bevel of the needle within an anterior chamber of the eye while advancing the pusher rod to advance the first end portion of the implant through the bevel of the needle while permitting the second end portion of the implant to remain within the needle.

16. The method of claim 13, positioning a bevel of the needle within an anterior chamber of the eye.

17. The method of claim 16, wherein the releasing comprises positioning the second end portion of the implant within the anterior chamber of the eye.

18. The method of claim 13, further comprising the step of contacting a sleeve, coupled to the needle, against an external surface of the eye, to restrict further longitudinal advancement of the needle into the eye.

19. An ab externo method of placing an intraocular implant into an eye, the method comprising the steps of:

advancing a needle, in which the implant is disposed, into the eye through conjunctiva and sclera of the eye, the implant comprising a drug deliverable to the eye;

positioning a bevel of the needle (i) within a choroidal space of the eye and an outflow portion of the implant within the choroidal space or (ii) within a vitreous space of the eye and the outflow portion of the implant within the vitreous space; and

releasing the intraocular implant to anchor the implant within an intrascleral space of the eye, wherein the implant functions as a plug to obstruct fluid flow from an anterior chamber of the eye toward the intrascleral space upon release.

20. The method of claim 19, wherein the implant comprises a tapered cross-sectional profile, the releasing comprising anchoring the implant by positioning a larger cross-sectional profile first end portion of the implant superficially within the sclera and a smaller cross-sectional profile second end portion deep to the first end portion.

21. The method of claim 19, wherein the implant comprises a conical shape in which a first end portion of the implant has a larger cross-sectional profile than a second end portion.