Method and system for preventing sore throat in humans
First Claim
1. A bioadhesive strip for treating sore throat in a human being, comprising:
- a solid strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 microns in at least a portion of said surface, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip is sized to extend over a majority of the soft palate, and wherein said strip includes one of an analgesic, and a lactic acid bacteria that coaggregates with S. pyogenes, and wherein a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system is employed to silence or to delete at least one virulence factor of S. pyogenes.
2 Assignments
0 Petitions
Accused Products
Abstract
A method and system to prevent sore throat infections in humans includes the administration of an active ingredient to a site on the mucus membranes of the throat of a human that inhibits adherence and promotes desorption of S. pyogenes to soft tissue surfaces, such as the pharyngeal and oral mucosa of a human. A mucoadhesive strip having a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human'"'"'s mouth is preferably employed and that has one or more encapsulated agents selected from the group consisting of an antibiotic; lactic acid bacteria; S. pyogenes modified by a CRISPR-Cas system to reduce one or more virulence factors; and a breath mint solution.
151 Citations
17 Claims
-
1. A bioadhesive strip for treating sore throat in a human being, comprising:
- a solid strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 microns in at least a portion of said surface, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip is sized to extend over a majority of the soft palate, and wherein said strip includes one of an analgesic, and a lactic acid bacteria that coaggregates with S. pyogenes, and wherein a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system is employed to silence or to delete at least one virulence factor of S. pyogenes.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 11)
-
9. A bioadhesive solid strip for treating sore throat in a human being, comprising:
- at least one surface of said strip having a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 microns in at least a portion of said at least one surface, said strip having a first and second side, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, said strip having a length dimension of between 0.5 and 2 cm;
a surface area of between 0.25-1.5 square inches;
a weight of at least 30 mg; and
includes bacteria modified by a CRISPR-Cas or Cfp1 system. - View Dependent Claims (10, 12, 13, 14, 15, 16, 17)
- at least one surface of said strip having a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 microns in at least a portion of said at least one surface, said strip having a first and second side, the first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, said strip having a length dimension of between 0.5 and 2 cm;
Specification