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Spheronized polymer particles

  • US 10,669,383 B2
  • Filed: 10/30/2007
  • Issued: 06/02/2020
  • Est. Priority Date: 10/31/2006
  • Status: Active Grant
First Claim
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1. A method of producing a spheroid polymer particle, comprising:

  • a. providing a mixture comprising a non-spheroid polymer particle and a liquid medium, wherein the polymer particle comprises one or more secondary components selected from the group consisting of pharmaceutical, biomolecule, imaging agent, targeting moiety, or magnetic particle, wherein the liquid medium comprises a surfactant; and

    wherein the polymer particle is at least partially insoluble in the liquid medium;

    b. heating the mixture above the glass transition temperature or the melting temperature of the polymer while mixing the mixture; and

    c. cooling the mixture to below the glass transition temperature or melting temperature of the polymer,thereby producing a spheroid polymer particle;

    wherein the non-spheroid polymer particle comprises a poly(lactide-glycolide) copolymer, lactide homopolymer, glycolide homopolymer, caprolactone, or a mixture thereof.

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