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Compositions and methods for epigenome editing

  • US 10,676,726 B2
  • Filed: 02/09/2016
  • Issued: 06/09/2020
  • Est. Priority Date: 02/09/2015
  • Status: Active Grant
First Claim
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1. A fusion protein comprising two heterologous polypeptide domains, wherein the first polypeptide domain comprises a Clustered Regularly Interspaced Short Palindromic Repeats associated (Cas) protein, wherein the second polypeptide domain comprises a p300 histone acetyltransferase effector domain, wherein the fusion protein activates transcription of a target gene by activating distal regulatory elements, and wherein the fusion protein comprises the polypeptide sequence of SEQ ID NO:

  • 140, SEQ ID NO;

    141, or SEQ ID NO;

    149.

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