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Oligosaccharide modification and labeling of proteins

  • US 10,676,771 B2
  • Filed: 12/20/2016
  • Issued: 06/09/2020
  • Est. Priority Date: 02/10/2006
  • Status: Active Grant
First Claim
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1. An antibody comprising a labeled oligosaccharide, wherein the labeled oligosaccharide comprises:

  • an azido-modified sugar attached to a GlcNAc residue on the antibody and the azido-modified sugar is N-azidogalactosamine (GalNAz); and

    a reporter molecule, a carrier molecule or a solid support comprising an activated alkyne group capable of reacting with said azido-modified sugar;

    wherein said reporter molecule, carrier molecule or solid support attaches to the azido group of the azido-modified sugar through the activated alkyne group.

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