Magnetic resonance apparatus and method for vascular imaging

• US 10,677,872 B2
• Filed: 05/21/2018
• Issued: 06/09/2020
• Est. Priority Date: 05/22/2017
• Status: Active Grant

• Current Assignee: Siemens Healthineers AG (Siemens AG)
• Original Assignee: Siemens Healthcare GMBH (Siemens AG)
• Inventors: Speier, Peter
• Primary Examiner(s): Vargas, Dixomara
• Application Number:
  US15/984,894
• Publication Number:
  US 20180335497A1
• Time in Patent Office: 750 Days
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/3875 using correction coil assemblies, e.g. active shimming
• CPC Class Codes: G01R 33/446 Multifrequency selective RF pulses, e.g. multinuclear acquisition mode spatially selective RF pulses G01R33/4833
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5605 by transferring coherence or polarization from a spin species to another, e.g. creating magnetization transfer contrast [MTC], polarization transfer using nuclear Overhauser enhancement [NOE]
• CPC Class Codes: G01R 33/5607 by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

In a magnetic resonance method and apparatus for time-of-flight vascular imaging, a magnetic field is applied to an imaging volume and an inflow volume, from which liquid enters into the imaging volume, of an examination person. The imaging volume is excited by an RF pulse, which fulfills a magnetization transfer function and a fat saturation function, while the magnetic field is being applied. The RF pulse has a frequency distribution whose frequencies are higher than the center frequency of water in the imaging volume, and that includes the fat frequency in the imaging volume. The magnetic field has a field distribution with an apex with essentially no spatial gradient in the imaging volume and having a higher spatial gradient in the inflow volume, so that the center frequency of water in the inflow volume is shifted in the direction of lower frequencies and is no longer affected by the RF pulse.

Claims

1. A method for vascular imaging using a magnetic resonance (MR) apparatus comprising:

using a computer to operate an MR data acquisition scanner, while an examination subject is situated therein, in order to apply a magnetic field to an imaging volume and to an inflow volume, from which liquid enters into the imaging volume of the examination subject;

using said computer to operate said MR data acquisition scanner in order to radiate a radio-frequency (RF) pulse that excites nuclear spins in said imaging volume while the magnetic field is being applied;

in said computer, generating control signals in order to radiate said RF pulse so as to fulfill a magnetization transfer function and a fat saturation function, giving said RF pulse a frequency distribution comprising frequencies that are higher than a center frequency of water in the imaging volume and said frequencies comprising the fat frequency in the imaging volume;

in said computer, generating control signals in order to apply said magnetic field with a magnetic field distribution approximated by a function that has an apex with substantially no gradient in said imaging volume and that has a higher spatial gradient in said inflow volume;

using said computer to operate said MR data acquisition scanner in order to acquire MR signals from the excited nuclear spins in the imaging volume that represent vessels in said imaging volume; and

in said computer, transforming data represented by MR signals into image data and presenting said image data at a display screen in communication with said computer in order to visualize said vessels.

2. A method as claimed in claim 1 comprising generating said control signals in order to give said magnetic field said magnetic field distribution using, as said function that approximates said magnetic field distribution, a mathematical function of at least the second order.

3. A method as claimed in claim 1 wherein said imaging volume and said inflow volume are each formed as respective slices having a longitudinal axis oriented perpendicularly to said imaging volume and said inflow volume and wherein, along said longitudinal axis, a slice thickness of the inflow volume is equal to a multiple of a slice thickness of the imaging volume.

4. A method as claimed in claim 3 comprising generating said control signals to apply said magnetic field so as to give said apex of said function that approximates said magnetic field distribution a thickness that is equal to the slice thickness of the imaging volume.

5. A method as claimed in claim 1 comprising also implementing said method in an execution for at least one further imaging volume and at least one further inflow volume and, in said execution for said at least one further imaging volume and said at least one further inflow volume, adjusting the magnetic field distribution to said at least one further imaging volume and to said at least one further inflow volume by giving the magnetic field distribution said apex in said at least one further imaging volume and said higher spatial gradient in said at least one further inflow volume.

6. A method as claimed in claim 5 comprising applying said magnetic field in said execution of said method for said at least one further imaging volume and said at least one further inflow volume so as to give said magnetic field distribution a linear spatial shift of the magnetic field distribution.

7. A method as claimed in claim 5 comprising applying said magnetic field in said execution of said method for said at least one further imaging volume and said at least one further inflow volume so as to change a linear component of the magnetic field distribution.

8. A method as claimed in claim 5 wherein said imaging volume and said at least one further domain at least partially overlap and wherein said inflow volume and said at least one further inflow volume also at least partially overlap.

9. A method as claimed in claim 1 comprising using said computer to operate said MR data acquisition scanner in order to radiate said RF pulse by superimposing a first RF pulse and a second RF pulse.

10. A method as claimed in claim 9 wherein said first RF pulse has a first flip angle and wherein said second RF pulse has a second flip angle that is different from said first flip angle.

11. A method as claimed in claim 9 wherein said first RF pulse has a flip angle in a range between 20 and 90 degrees and a frequency substantially equal to said fat frequency in the imaging volume.

12. A method as claimed in claim 1 comprising using said computer to operate said MR data acquisition scanner to obtain a plurality of acquisitions of said MR signals from said imaging volume for each radiated RF pulse.

13. A method as claimed in claim 12 comprising using said computer to operate said MR data acquisition scanner to execute respective acquisitions in said plurality of acquisitions at regular time intervals.

14. A method as claimed in claim 12 comprising using said computer to operate said MR data acquisition scanner to execute acquisitions in said plurality of acquisitions in measurement groups with time intervals between individual acquisitions in each acquisition group, and by radiating an RF pulse between each acquisition group, with an average time interval between acquisitions being shorter than a predetermined threshold value.

15. A magnetic resonance (MR) apparatus comprising:

an MR data acquisition scanner comprising a basic field magnet and a radio-frequency (RF) radiator;

a computer configured to operate said MR data acquisition scanner, while an examination subject is situated therein, in order to apply a magnetic field with said basic field magnet to an imaging volume and to an inflow volume, from which liquid enters into the imaging volume of the examination subject;

said computer being configured to operate said MR data acquisition scanner in order to radiate a radio-frequency (RF) pulse from said RF radiator that excites nuclear spins in said imaging volume while the magnetic field is being applied;

said computer being configured to generate control signals to said Rf radiator in order to radiate said RF pulse so as to fulfill a magnetization transfer function and a fat saturation function, giving said RF pulse a frequency distribution comprising frequencies that are higher than a center frequency of water in the imaging volume and said frequencies comprising the fat frequency in the imaging volume;

said computer being configured to generate control signals to said basic filed magnet in order to apply said magnetic field with a magnetic field distribution approximated by a function that has an apex with substantially no gradient in said imaging volume and that has a higher spatial gradient in said inflow volume;

said computer being configured to operate said MR data acquisition scanner in order to acquire MR signals from the excited nuclear spins in the imaging volume that represent vessels in said imaging volume; and

said computer being configured to transform data represented by MR signals into image data and to present said image data at a display screen in communication with said computer in order to visualize said vessels.

16. A non-transitory, computer-readable data storage medium encoded with programming instructions, said storage medium being loaded into a computer of a magnetic resonance (MR) apparatus that comprises an MR data acquisition scanner, said programming instructions causing said computer system to:

operate said MR data acquisition scanner, while an examination subject is situated therein, in order to apply a magnetic field to an imaging volume and to an inflow volume, from which liquid enters into the imaging volume of the examination subject;

operate said MR data acquisition scanner in order to radiate a radio-frequency (RF) pulse that excites nuclear spins in said imaging volume while the magnetic field is being applied;

generate control signals in order to radiate said RF pulse so as to fulfill a magnetization transfer function and a fat saturation function, giving said RF pulse a frequency distribution comprising frequencies that are higher than a center frequency of water in the imaging volume and said frequencies comprising the fat frequency in the imaging volume;

generate control signals in order to apply said magnetic field with a magnetic field distribution approximated by a function that has an apex with substantially no gradient in said imaging volume and that has a higher spatial gradient in said inflow volume;

operate said MR data acquisition scanner in order to acquire MR signals from the excited nuclear spins in the imaging volume that represent vessels in said imaging volume; and

transform data represented by MR signals into image data and present said image data at a display screen in communication with said computer in order to visualize said vessels.