Systems and methods for determining tissue type
First Claim
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1. A method for monitoring tissue ablation comprising:
- receiving light returned from a tissue; and
generating a graph of at least one of a collagen peak indicative of an amount of collagen in the tissue and an NADH fluorescence peak indicative of an amount of myocardium in the tissue, wherein a wavelength of the collagen peak is indicative of a relative amount of collagen and myocardium in the tissue;
displaying the graph representing the relative amount of collagen and myocardium in the tissue for the selection of an ablation strategy for a lesion formation in the tissue, the ablation strategy including the selection of one or more of an ablation energy type, an ablation energy power, duration of delivery of ablation energy, and ablation temperature limits of the ablation energy.
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Abstract
Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.
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Citations
28 Claims
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1. A method for monitoring tissue ablation comprising:
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receiving light returned from a tissue; and generating a graph of at least one of a collagen peak indicative of an amount of collagen in the tissue and an NADH fluorescence peak indicative of an amount of myocardium in the tissue, wherein a wavelength of the collagen peak is indicative of a relative amount of collagen and myocardium in the tissue; displaying the graph representing the relative amount of collagen and myocardium in the tissue for the selection of an ablation strategy for a lesion formation in the tissue, the ablation strategy including the selection of one or more of an ablation energy type, an ablation energy power, duration of delivery of ablation energy, and ablation temperature limits of the ablation energy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for monitoring tissue ablation comprising:
a catheter comprising; a catheter body; and a distal tip positioned at a distal end of the catheter body; an ablation system in communication with the distal tip to deliver ablation energy to the distal tip; a visualization system comprising a light source, a light measuring instrument, and one or more optical fibers in communication with the light source and the light measuring instrument and extending through the catheter body to the distal tip, wherein the one or more optical fibers are configured to pass light to a tissue and collect light returned from the tissue; and a processor in communication with the light measuring instrument, the processor being programmed to; receive data relating to the light returned from the tissue illuminated with the light from the light source; generate a graph of at least one of a collagen peak indicative of an amount of collagen in the tissue and an NADH fluorescence peak indicative of an amount of myocardium in the tissue, wherein a wavelength of the collagen peak is indicative of a relative amount of collagen and myocardium in the tissue, and display the graph representing the relative amount of collagen and myocardium in the tissue for the selection of an ablation strategy for a lesion formation in the tissue, the ablation strategy including the selection of one or more of an ablation energy type, an ablation energy power, duration of delivery of ablation energy, and ablation temperature limits of the ablation energy. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A method for monitoring tissue ablation comprising:
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receiving light returned from a tissue; generating a graph of a collagen peak indicative of an amount of collagen in the tissue; and displaying the graph representing the amount of collagen in the tissue for the adjustment of one or more characteristics of ablation parameters based on the amount of collagen in the tissue for a lesion formation in the tissue, the ablation parameters including at least one of an ablation energy type, an ablation energy power, duration of delivery of ablation energy, and ablation temperature limits of the ablation energy. - View Dependent Claims (22, 23, 24, 25, 26)
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27. A system for monitoring tissue ablation comprising:
a catheter comprising; a catheter body; and a distal tip positioned at a distal end of the catheter body; an ablation system in communication with the distal tip to deliver ablation energy to the distal tip; a visualization system comprising a light source, a light measuring instrument, and one or more optical fibers in communication with the light source and the light measuring instrument and extending through the catheter body to the distal tip, wherein the one or more optical fibers are configured to pass light to a tissue and collect light returned from the tissue; and a processor in communication with the light measuring instrument, the processor being programmed to; receive data relating to the light returned from the tissue illuminated with the light through the distal tip of the catheter; generate a graph of a collagen peak indicative of an amount of collagen in the tissue, and display the graph representing the amount of collagen in the tissue for the adjustment of one or more characteristics of ablation parameters based on the amount of collagen in the tissue for a lesion formation in the tissue, wherein the characteristics including at least one of an ablation energy type, an ablation energy power, duration of delivery of ablation energy, and ablation temperature limits of the ablation energy. - View Dependent Claims (28)
Specification