Pharmaceutical products from fungal strains

• US 10,682,380 B2
• Filed: 08/12/2016
• Issued: 06/16/2020
• Est. Priority Date: 08/11/2010
• Status: Active Grant

• Current Assignee: Menon Renewable Products, Inc. (Menon & Associates, Inc.)
• Original Assignee: Menon Renewable Products, Inc. (Menon & Associates, Inc.)
• Inventors: Menon, Suresh, Orchard, Samantha S, Badger, Jessica, Lipson, David, Guidi, Sara, Sircar, Jagadish C, Alisala, Kashinatham
• Primary Examiner(s): Wu, Julie
• Assistant Examiner(s): White, Douglas F
• Application Number:
  US15/236,286
• Publication Number:
  US 20170065651A1
• Time in Patent Office: 1,404 Days
• Field of Search: None
• CPC Class Codes: A61K 36/06 Fungi, e.g. yeasts
• CPC Class Codes: A61K 36/062 Ascomycota
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: C12M 27/02 Stirrer or mobile mixing elements
• CPC Class Codes: C12M 27/20 Baffles; Ribs; Ribbons; Auger vanes
• CPC Class Codes: C12N 1/145 Fungal isolates
• CPC Class Codes: C12P 1/02 by using fungi
• CPC Class Codes: C12P 2203/00 Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source ethanol C12P7/10
• CPC Class Codes: C12R 2001/80 Penicillium

Abstract

Disclosed herein are compositions comprising an isolated cellulose degrading fungus and pharmaceutical substances produced by the fungus.

Claims

1. An animal feed formulation to provide increased resistance to infection comprising:

animal feed, and

and an antibiotic amount of a fungal biomass comprising the biomass of a cellulose degrading fungus and a conditioned medium comprising an inhibitory substance, wherein said medium is conditioned by the cellulose degrading fungus cultured in a bioreactor on a feedstock that does not contain added glycerol,

wherein said cellulose degrading fungus comprises a characteristic selected from the group consisting of;

a 5.8S ribosomal RNA gene sequence having at least 98% nucleotide sequencing identity with the nucleic acid of SEQ ID NO;

1;

an ITS1 sequence with at least 98% sequence identity to SEQ ID NO;

2;

an ITS2 sequence with at least 98% sequence identity to SEQ ID NO;

3; and

a 28S ribosomal RNA gene sequence with at least 98% sequence identity to SEQ ID NO;

4, and

wherein the animal feed formulation comprises 1% to 90% fungal biomass by weight, and the animal feed provides nutrition in addition to the fungal biomass.

2. The animal feed formulation of claim 1, wherein said cellulose degrading fungus comprises a species being the same as NRRL deposit Accession No:

50410.

3. The animal feed formulation of claim 1, wherein the animal feed formulation is suitable for consumption by an animal selected from the group consisting of:

cows, birds, pigs, cats, dogs, humans, rodents, fish, shrimp, prawns, and aquatic mammals.

4. The animal feed formulation of claim 1, wherein the animal feed formulation is suitable for consumption by chickens or shrimp.

5. The animal feed formulation of claim 1, wherein the fungal biomass is a dried fungal biomass.

6. The animal feed formulation of claim 1, wherein said inhibitory substance is an antimicrobial substance.

7. The animal feed formulation of claim 1, wherein said inhibitory substance is a bacteriostatic agent.

8. The animal feed formulation of claim 1, wherein said inhibitory substance is a bacteriocidal agent.

9. The animal feed formulation of claim 1, wherein said inhibitory substance is a bacteriocidal agent against Gram-negative bacterium.

10. The animal feed formulation of claim 9, wherein said inhibitory substance is a bacteriocidal agent against Gram-positive bacterium.