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Antisense nucleic acids

DC CAFC
  • US 10,683,322 B2
  • Filed: 12/17/2019
  • Issued: 06/16/2020
  • Est. Priority Date: 09/01/2010
  • Status: Active Grant
First Claim
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1. A solid-phase method of making an oligomer comprising a phosphorodiamidate morpholino oligomer (PMO) and a group at the 5′

  • end of said PMO, wherein said PMO is 100% complementary to the 36th to the 60th nucleotides from the 5′

    end of the 53rd exon in a human dystrophin pre-mRNA, wherein the 53rd exon in said human dystrophin pre-mRNA consists of a nucleotide sequence corresponding to SEQ ID NO;

    1, wherein said PMO hybridizes to said human dystrophin pre-mRNA with Watson-Crick base pairing, wherein the phosphorodiamidate morpholino monomers of said PMO have the formula;

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