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Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs

  • US 10,683,342 B2
  • Filed: 06/08/2016
  • Issued: 06/16/2020
  • Est. Priority Date: 04/24/2008
  • Status: Active Grant
First Claim
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1. A library of vectors or genetic packages, wherein the vectors or genetic packages comprise variegated DNA sequences, each encoding a heavy chain (HC) variable region, which comprises three complementarity determining regions (CDRs) 1-3 and framework regions (FRs) 1-4, arranged from the amino terminus to the carboxy-terminus in an order of FR1-CDR2-FR2-CDR2-FR3-CDR3-FR4, wherein the HC CDR3 region contains 3-35 amino acid residues, and wherein at least 1, 2, 3, 4, 5, 6, 7, or 8 positions in the HC CDR3s encoded by the variegated DNA sequences are varied among Tyr, Gly, Asp, Ser, Arg, and Leu residues.

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