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Measuring concertation of analytes in liquid samples using surface-enhanced Raman spectroscopy

  • US 10,684,267 B2
  • Filed: 09/04/2019
  • Issued: 06/16/2020
  • Est. Priority Date: 09/16/2015
  • Status: Active Grant
First Claim
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1. A method of measuring the amount of an analyte in water, the method comprising the steps of:

  • obtaining a sample of water of known volume containing an analyte;

    mixing a known amount of an isotopologue with the sample;

    mixing Raman-scattering nanoparticles with the sample;

    producing a Raman spectrum of the mixture; and

    ,performing a ratiometric analysis of peaks or bands within the Raman spectrum corresponding to the analyte and the isotopologue within the Raman spectrum to quantify the analyte,wherein the analyte is a molecular anion and the isotopologue is a molecular anion with all oxygen atoms substituted with 18O.

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