Sample processing system for processing biological samples

• US 10,684,301 B2
• Filed: 04/28/2017
• Issued: 06/16/2020
• Est. Priority Date: 05/24/2012
• Status: Active Grant

• Current Assignee: Hamilton Bonaduz AG (Hamilton Company)
• Original Assignee: Hamilton Bonaduz AG (Hamilton Company)
• Inventors: Giovanoli, Nando
• Primary Examiner(s): Hyun, Paul S
• Application Number:
  US15/581,194
• Publication Number:
  US 20170227562A1
• Time in Patent Office: 1,145 Days
• CPC Class Codes: B01F 29/31 the containers being supported by driving means, e.g. by rotating rollers
• CPC Class Codes: B01F 29/80 rotating about a substantially vertical axis
• CPC Class Codes: G01N 2035/00366 Several different temperatures used
• CPC Class Codes: G01N 2035/00524 Mixing by agitating sample carrier
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/0405 manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
• CPC Class Codes: G01N 2035/0429 Sample carriers adapted for special purposes
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: G01N 35/1074 arranged in a two-dimensional array
• CPC Class Codes: G01N 35/1083 with one horizontal degree of freedom

Abstract

The invention relates to a sample processing system and method for processing biological samples, comprising a sample processing device having: a receiving plate, which is arranged substantially horizontally in a plane; a first and second working arm, which can move relative to the receiving plate and extend substantially parallel to each other in a second direction (Y) over the receiving plate; at least one pipetting device mounted on the first working arm, which is movable in the second direction (Y) and in a third direction (Z) orthogonal in relation to the first and second direction (X, Y); at least one gripping device, mounted on the second working arm, with grippers that can be rotated around a gripper axis of rotation (GA) parallel to the third direction (Z); and a control device for controlling the pipetting device and the gripping device.

Claims

1. A processing method for biological samples, comprising the steps:

providing at least one sample container carrier,

placing at least one closed sample container in which a biological sample liquid is contained into the at least one sample container carrier at an initial rotation position, wherein each of the at least one closed sample container comprises a closing element;

moving the at least one sample container carrier onto a receiving plate of a sample processing device;

gripping the at least one closed sample container in the at least one sample container carrier by means of a gripping device of the sample processing device;

mixing the biological sample liquid contained within the at least one sample container by rotating the at least one sample container by means of the gripping device;

placing the at least one sample container at a desired position in the sample processing device by means of the gripping device;

detaching a closing element of the at least one closed sample container by means of a closing device and the gripping device of the sample processing device for further processing; and

closing the at least one sample container with the detached closing element or an unused closing element by means of the closing device after said further processing.

2. The processing method according to claim 1, further comprising providing of at least one pipetting tip carrier with unused pipetting tips and moving the at least one pipetting tip carrier onto the receiving plate of the sample processing device.

3. The processing method according to claim 2, further comprising the following steps:

collecting a pipetting tip from the pipetting tip carrier by means of a pipetting device;

aspirating a desired amount of the biological sample liquid from a specific sample container of the at least one sample container;

dispensing the biological sample liquid accommodated within the pipetting tip into an empty sample container; and

disposing of the used pipetting tip.

4. The processing method according to claim 3, further comprising repeating the steps.

5. The processing method according to claim 1, wherein the at least one closed sample container which contains the biological sample liquid, is a sample container of a first type and wherein the method further comprises the following steps:

providing at least one unclosed sample container of a second type in a second sample container carrier, wherein the second sample container carrier is distinct from the at least one sample container carrier, wherein the at least one closed sample container of the first type comprises an identification pattern the at least one unclosed sample container of the second type comprises the identification pattern.

6. The processing method according to claim 5, wherein the at least one unclosed sample container of the second type is empty.

7. The processing method according to claim 5, comprising detecting and storing the identification pattern on the at least one closed sample container.

8. The processing method according to claim 7, further comprising:

detecting, by means of a sensor on the gripping device, the identification pattern; and

wherein placing the at least one closed sample container at a desired position in the sample processing device by means of the gripping device comprises placing the at least one closed sample container in a predetermined rotation position relative to the initial rotation position, wherein the predetermined rotation position aligns with rotation positions of a plurality of the at least one sample container placed into the at least one sample container carrier.

9. The processing method according to claim 7, wherein the at least one unclosed sample container of the second type is empty.

10. The processing method according to claim 1, wherein said providing step is performed outside of the sample processing device on a providing area in front of the sample processing device.

11. The processing method according to claim 1, further comprising the steps:

automated moving of the at least one sample container carrier from the receiving plate of the sample processing device to a providing surface of the sample processing device and manually taking out the at least one sample container carrier from the sample processing device.

12. The processing method according to claim 1, further comprising providing a closing element carrier with unused closing elements for the at least one sample container.

13. The processing method according to claim 12, further comprising manual positioning of the closing element carrier on the receiving plate of the sample processing device.

14. The processing method according to claim 1, wherein mixing of the biological sample liquid in the at least one sample container is performed by means of the gripping device after transport of the at least one sample container into a region of a disposal container.

15. The processing method according to claim 1, further comprising repeating the steps.

16. The processing method according to claim 1, wherein the step of detaching a closing element of the at least one closed sample container comprises the following steps:

placing the at least one sample container into said closing device;

generating a loose engagement between the closing element of the at least one sample container accommodated within the closing device by means of the closing device; and

detaching the loosely engaged closing element from the at least one sample container and from the closing device by means of the gripping device;

thereby canceling an engagement between the closing element and the at least one sample container.

17. The processing method according to claim 16, wherein the step of closing the at least one sample container with the detached closing element or an unused closing element comprises the following steps:

placing the previously detached closing element or placing an unused closing element onto the at least one sample container located within the closing device by means of the gripping device;

loosely screwing the closing element onto the at least one sample container by means of the gripping device conducting at least one partial revolution of the closing element;

reclosing the at least one sample container located within the closing device by means of the closing device;

removing the resulting reclosed at least one sample container from the closing device by means of the gripping device; and

placing the reclosed at least one sample container into the at least one sample container carrier.

18. The processing method according to claim 17, further comprising repeating the steps for a plurality of sample containers, the plurality of sample containers comprising a different set of sample containers than the at least one sample container.

19. The processing method according to claim 17, wherein the at least one sample container carrier comprises a first sample container carrier and a second sample container carrier, wherein placing at least one closed sample container in which a biological sample liquid is contained into the at least one sample container carrier comprises placing the at least one closed sample container into the first sample container carrier.

20. The processing method according to claim 16, further comprising repeating the steps for a plurality of sample containers, the plurality of sample containers comprising a different set of sample containers than the at least one sample container.

21. A method for processing a biological sample, comprising providing a sample container carrier,

placing a closed sample container into the sample container carrier, wherein a biological sample liquid is contained in the closed sample container,

moving the sample container carrier onto a receiving plate of a sample processing device,

gripping the closed sample container in the sample container carrier by means of a gripping device in the sample processing device,

mixing the biological sample liquid contained in the closed sample container by rotating the closed sample container by means of the gripping device,

placing the sample container at a desired position in the sample processing device by means of the gripping device for further processing,

placing the sample container into a closing device,

generating a loose engagement of a closing element of the sample container by means of the closing device,

removing the loosely engaged closing element from the sample container and from the closing device by means of the gripping device;

placing the previously removed closing element or placing an unused closing element onto the sample container located within the closing device by means of the gripping device;

loosely screwing the closing element onto the sample container by means of the gripping device conducting at least one partial revolution of the closing element;

reclosing the sample container located within the closing device by means of the closing device;

removing the resulting reclosed sample container from the closing device by means of the gripping device; and

placing the reclosed sample container into the sample container carrier.