System, device, and method for determination of intraocular pressure

• US 10,687,704 B2
• Filed: 12/30/2010
• Issued: 06/23/2020
• Est. Priority Date: 12/30/2009
• Status: Active Grant

• Current Assignee: Ioptic Incorporated, University Of Kentucky Research Foundation (University of Kentucky)
• Original Assignee: University Of Kentucky Research Foundation (University of Kentucky)
• Inventors: Hastings, Jeffrey Todd, Brockman, E. Britt, St. Omer, Ingrid L., Wright, John C.
• Primary Examiner(s): Henson, Devin B
• Assistant Examiner(s): Nguyen, H. Q.
• Application Number:
  US12/982,110
• Publication Number:
  US 20110160561A1
• Time in Patent Office: 3,463 Days
• Field of Search: 600398
• CPC Class Codes: A61B 3/165 Non-contacting tonometers

Abstract

A system for determination of intraocular pressure includes: an intraocular pressure sensor; a light source illuminating the sensor with one or more wavelengths of light; and a detector that measures emitted light from the sensor. The sensor includes a substrate member, a spacer member, and a flexible membrane, which define a sealed cavity. The flexible membrane moves in response to intraocular pressure changes. A device for measuring intraocular pressure includes: the sensor; an anchoring member attached to the sensor for immobilizing the sensor in an eye; and a protective member attached to the anchoring member and covering the sensor to prevent contact between the flexible membrane and the eye. A method for determination of intraocular pressure includes: placing the sensor in an eye; illuminating, with a light source, the sensor with one or more wavelengths of light; and detecting, with a detector, a resultant light that contains information about intraocular pressure.

Claims

1. An intraocular pressure sensor for implantation in an eye, comprising:

a substrate member;

a spacer member; and

a flexible membrane;

the substrate member, the spacer member and the flexible membrane forming the walls of a sealed cavity having no openings for fluid communication with a vacuum, and forming the intraocular pressure sensor configured for implantation in the eye;

the flexible membrane configured to deform in response to intraocular pressure changes and wherein the deformation of the flexible membrane can be measured optically;

the flexible membrane configured to partially transmit and partially reflect an incident light that is incident on an exterior surface of the flexible membrane when the intraocular pressure sensor is implanted in the eye, and the substrate member configured to reflect the incident light that is partially transmitted by the flexible membrane back through the flexible membrane;

wherein the incident light reflected by the substrate member interferes with incident light reflected by the flexible membrane to create a resultant light comprising an interference pattern consisting of bright and dark rings having a separation depending on a curvature of the flexible membrane;

wherein the resulting interference pattern is capturable as an image using a camera and corresponds to intraocular pressure; and

wherein the sealed cavity has a pressure below one atmosphere.

2. The intraocular pressure sensor of claim 1, wherein the material dimensions of the flexible membrane provide a number of periods in the interference pattern to estimate phase within ±

0.03 radians such that intraocular pressure can be measured with an accuracy of 1 mm Hg over a range of 610 to 820 mmHg absolute pressure.

3. The intraocular pressure sensor of claim 1, the material and dimensions of the flexible membrane configured to prevent the membrane from contacting the bottom of the sealed cavity under pressures encountered in the intraocular environment.

4. The intraocular pressure sensor of claim 1, the materials and dimensions of the flexible membrane configured to limit pressure measurement errors to less than 1 mm Hg in the presence of temperature fluctuations from 32°

C. to 36°

C. encountered in the intraocular environment.

5. The intraocular pressure sensor of claim 1, wherein the material and dimensions of the flexible membrane and the thickness of the spacer member provide the interference pattern without using a light source that relies on laser action.

7. The intraocular pressure sensor of claim 1, the material and dimensions of the membrane configured to limit the phase change in the interference pattern to less than 2π

over a range of 610 to 820 mmHg absolute pressure.

6. An intraocular pressure sensor for implantation in an eye, comprising:

a substrate member;

a spacer member; and

a flexible membrane;

the substrate member, the spacer member and the flexible membrane forming the walls of a sealed cavity having no openings for fluid communication with a vacuum, and forming the intraocular pressure sensor configured for implantation in the eye;

the flexible membrane configured to deform in response to intraocular pressure changes and wherein the deformation of the flexible membrane can be measured optically;

the flexible membrane configured to partially transmit and partially reflect an incident light that is incident on an exterior surface of the flexible membrane when the intraocular pressure sensor is implanted in the eye, and the substrate member configured to reflect the incident light that is partially transmitted by the flexible membrane back through the flexible membrane;

wherein the incident light reflected by the substrate member interferes with incident light reflected by the flexible membrane to create a resultant light comprising an interference pattern consisting of bright and dark rings having a separation depending on a curvature of the flexible membrane; and

wherein the resulting interference pattern is capturable as an image using a camera and corresponds to intraocular pressure; and

further comprising a layer of additional material coated on the external side of the flexible membrane, the thickness and refractive index of the additional material configured to equalize the incident light reflected by the substrate member and the incident light reflected by the flexible membrane.