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Formation of delivery agents targeted to degraded elastic fibers

  • US 10,688,061 B2
  • Filed: 02/01/2017
  • Issued: 06/23/2020
  • Est. Priority Date: 06/28/2012
  • Status: Active Grant
First Claim
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1. A method of forming a delivery agent, the method comprising:

  • forming a micro- or nano-sized biodegradable particle, the biodegradable particle comprising a biocompatible polymer;

    associating a biologically active agent with the particle, the biologically active agent comprising a tannin, a flavonoid, a flavolignan, a phenolic rhizome, a favan-3-ol a cathepsins inhibitor, an MMP inhibitor, an elastase inhibitor, a lysyl oxidase, copper ions, forskolin, TGF-β

    , ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid, Nitrilotriacetic acid, hydroxyethyl ethylenediaminetriacetic acid, 8-Hydroxy-7-iodo-5-quinolinesulfonic acid, poly(gamma-glutamic acid, sodium thiosulphate, or alpha-lipoic acid; and

    attaching an anchoring agent to a surface of the biodegradable particle, the anchoring agent comprising an anti-elastin antibody or a fragment thereof that specifically binds amorphous cross-linked elastin.

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