Formation of delivery agents targeted to degraded elastic fibers
First Claim
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1. A method of forming a delivery agent, the method comprising:
- forming a micro- or nano-sized biodegradable particle, the biodegradable particle comprising a biocompatible polymer;
associating a biologically active agent with the particle, the biologically active agent comprising a tannin, a flavonoid, a flavolignan, a phenolic rhizome, a favan-3-ol a cathepsins inhibitor, an MMP inhibitor, an elastase inhibitor, a lysyl oxidase, copper ions, forskolin, TGF-β
, ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid, Nitrilotriacetic acid, hydroxyethyl ethylenediaminetriacetic acid, 8-Hydroxy-7-iodo-5-quinolinesulfonic acid, poly(gamma-glutamic acid, sodium thiosulphate, or alpha-lipoic acid; and
attaching an anchoring agent to a surface of the biodegradable particle, the anchoring agent comprising an anti-elastin antibody or a fragment thereof that specifically binds amorphous cross-linked elastin.
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Abstract
Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.
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Citations
21 Claims
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1. A method of forming a delivery agent, the method comprising:
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forming a micro- or nano-sized biodegradable particle, the biodegradable particle comprising a biocompatible polymer; associating a biologically active agent with the particle, the biologically active agent comprising a tannin, a flavonoid, a flavolignan, a phenolic rhizome, a favan-3-ol a cathepsins inhibitor, an MMP inhibitor, an elastase inhibitor, a lysyl oxidase, copper ions, forskolin, TGF-β
, ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid, Nitrilotriacetic acid, hydroxyethyl ethylenediaminetriacetic acid, 8-Hydroxy-7-iodo-5-quinolinesulfonic acid, poly(gamma-glutamic acid, sodium thiosulphate, or alpha-lipoic acid; andattaching an anchoring agent to a surface of the biodegradable particle, the anchoring agent comprising an anti-elastin antibody or a fragment thereof that specifically binds amorphous cross-linked elastin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification