Medical device for modification of left atrial appendage and related systems and methods

• US 10,695,070 B2
• Filed: 07/31/2017
• Issued: 06/30/2020
• Est. Priority Date: 01/08/2009
• Status: Active Grant

• Current Assignee: Coherex Medical, Inc. (Johnson & Johnson)
• Original Assignee: Coherex Medical, Inc. (Johnson & Johnson)
• Inventors: Miles, Scott D., Edmiston, Daryl R., Davis, Clark C.
• Primary Examiner(s): Hollm, Jonathan A
• Application Number:
  US15/665,412
• Publication Number:
  US 20170325820A1
• Time in Patent Office: 1,065 Days
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/0487 Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks suture anchors A61B17/0401; wound clamps or clips A61B17/08; ligaturing clamps or clips A61B17/122
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12159 Solid plugs; being solid before insertion
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00575 for closure at remote site, e.g. closing atrial septum defects
• CPC Class Codes: A61B 2017/00579 Barbed implements
• CPC Class Codes: A61B 2017/00588 Rigid or stiff implements, e.g. made of several rigid parts linked by hinges
• CPC Class Codes: A61B 2017/00592 Elastic or resilient implements
• CPC Class Codes: A61B 2017/00597 : Implements comprising a membrane
• CPC Class Codes: A61B 2017/00601 : Implements entirely comprised between the two sides of the opening
• CPC Class Codes: A61B 2017/0061 : Implements located only on one side of the opening
• CPC Class Codes: A61B 2017/00632 : Occluding a cavity, i.e. closing a blind opening
• CPC Class Codes: A61B 2017/00867 : shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00884 : enhancing wound closure
• CPC Class Codes: A61B 2017/0409 : Instruments for applying suture anchors for applying suture clamps, clips or locks A61B2017/0488
• CPC Class Codes: A61B 2017/0412 : having anchoring barbs or pins extending outwardly from suture anchor body
• CPC Class Codes: A61B 2017/0414 : having a suture-receiving opening, e.g. lateral opening lateral eyelet for attaching suture to needle A61B2017/06019
• CPC Class Codes: A61B 2017/0437 : the barbs being resilient or spring-like
• CPC Class Codes: A61B 2017/0446 : Means for attaching and blocking the suture in the suture anchor
• CPC Class Codes: A61B 2017/0448 : Additional elements on or within the anchor
• CPC Class Codes: A61B 2017/0459 : Multiple holes in the anchor through which the suture extends and locking the suture when tension is applied
• CPC Class Codes: A61B 2017/0464 : for soft tissue
• CPC Class Codes: A61B 2017/1205 : Introduction devices
• CPC Class Codes: Y10T 29/49826 : Assembling or joining

Abstract

A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure. Each frame segment includes a hub portion and at least one leg portion, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member, and the at least one leg portion extending from the hub portion. With this arrangement, a tissue growth member is coupled to the frame segments.

Claims

1. A method for modifying a left atrial appendage of a heart, the method comprising:

advancing a medical device with a catheter of a delivery system through a vasculature and into the left atrial appendage of the heart such that the medical device is advanced in a constricted state, the medical device including a plurality of frame portions coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the plurality of frame portions configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure; and

deploying the medical device from the delivery system within the left atrial appendage such that the frame structure moves to an expanded state and such that a tissue growth member coupled to the plurality of frame portions engages tissue within the left atrial appendage.

2. The method according to claim 1, wherein the advancing the medical device comprises advancing the medical device that includes a hub portion and a leg portion of each of the plurality of frame portions, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member with the leg portion extending from the hub portion such that the leg portion is moveable between the constricted state and the expanded state.

3. The method according to claim 1, wherein the deploying the medical device comprises engaging the tissue of the left atrial appendage with the tissue growth member of the medical device, the tissue growth member including a porous material.

4. The method according to claim 1, wherein the deploying the medical device comprises engaging the tissue of the left atrial appendage with the tissue growth member of the medical device, the tissue growth member including expanded polytetrafluoroethylene.

5. The method according to claim 1, wherein the deploying the medical device comprises expanding a portion of the plurality of frame portions radially outward so that the tissue growth member coupled thereto engages the tissue of the left atrial appendage.

6. The method according to claim 1, further comprising releasing the catheter from the medical device and withdrawing the delivery system from the vasculature to permanently leave the medical device in the left atrial appendage.

7. The method according to claim 1, further comprising anchoring the medical device within the left atrial appendage.

8. A method for modifying a left atrial appendage of a heart, the method comprising:

advancing a medical device with a catheter of a delivery system through a vasculature and into the left atrial appendage of the heart such that the medical device is advanced in a constricted state; and

deploying the medical device from the delivery system within the left atrial appendage such that multiple frame portions of a frame structure of the medical device moves to an expanded state, the multiple frame portions coupled to at least one ring member having an inner surface defining notches radially spaced therein, each of the multiple frame portions including a portion positioned within one of the notches of the at least one ring member to collectively form the frame structure.

9. The method according to claim 8, wherein the deploying the medical device comprises deploying a tissue growth member coupled to the multiple frame portions such that the tissue growth member is biased by the multiple frame portions against tissue within the left atrial appendage.

10. The method according to claim 8, wherein the deploying the medical device comprises expanding a portion of the plurality of frame portions radially outward so that a tissue growth member coupled thereto engages the tissue of the left atrial appendage.

11. The method according to claim 8, further comprising anchoring the medical device within the left atrial appendage.

12. The method according to claim 8, further comprising releasing the catheter from the medical device and withdrawing the delivery system from the vasculature to permanently leave the medical device in the left atrial appendage.

13. The method according to claim 8, wherein the deploying the medical device comprises engaging the tissue of the left atrial appendage with a tissue growth member of the medical device, the tissue growth member including a porous material.

14. The method according to claim 8, wherein the deploying the medical device comprises engaging the tissue of the left atrial appendage with a tissue growth member of the medical device, the tissue growth member including expanded polytetrafluoroethylene.

15. A method for modifying a left atrial appendage of a heart, the method comprising:

advancing a medical device with a catheter of a delivery system through a vasculature and into the left atrial appendage of the heart such that the medical device is advanced in a constricted state; and

deploying the medical device from the delivery system within the left atrial appendage such that multiple frame portions of the medical device move to a radially expanded state with a portion of each of the multiple frame portions maintaining a fixed position relative to at least one ring member having an inner surface defining notches radially spaced therein, the portion of each of the multiple frame portions positioned within one of the notches of the at least one ring member.

16. The method according to claim 15, further comprising anchoring the medical device to tissue within the left atrial appendage.

17. The method according to claim 15, wherein the deploying the medical device comprises deploying a tissue growth member coupled to the multiple frame portions such that the tissue growth member is biased by the multiple frame portions against tissue within the left atrial appendage.

18. The method according to claim 15, wherein the deploying the medical device comprises expanding portions of the plurality of frame portions radially outward so that a tissue growth member coupled thereto contacts the tissue within the left atrial appendage.

19. The method according to claim 15, further comprising releasing the catheter from the medical device and withdrawing the delivery system from the vasculature to permanently leave the medical device in the left atrial appendage.

20. The method according to claim 15, wherein the deploying the medical device comprises engaging the tissue of the left atrial appendage with a tissue growth member of the medical device, the tissue growth member including a porous material.