Anti-thrombogenic medical devices

• US 10,695,200 B2
• Filed: 02/15/2019
• Issued: 06/30/2020
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Wainwright, John, Mendelson, Todd, Haggstrom, Kurt, Molaei, Masoud, Schuman, Victoria, Sheu, Min-Shyan
• Primary Examiner(s): Dukert, Brian A
• Application Number:
  US16/277,170
• Publication Number:
  US 20190175373A1
• Time in Patent Office: 501 Days
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/966 with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2002/9665 with additional retaining means
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0023 differing in porosity
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2310/00389 The prosthesis being coated or covered with a particular material
• CPC Class Codes: B05D 1/18 performed by dipping
• CPC Class Codes: B05D 3/0272 with ovens
• CPC Class Codes: B05D 3/04 by exposure to gases

Abstract

Medical devices that include a tubular member with a plurality of braided filaments, each filament crossing another of the filaments at a respective crossing point forming sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores have an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device with pores substantially free of webs formed by antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by antithrombogenic material thereby permitting the pores to be substantially free of webs.

Claims

1. A medical device for treating an aneurysm, comprising:

a tubular member comprising a plurality of braided filaments that form a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, each of the filaments crossing another of the filaments at a respective crossing point; and

an antithrombogenic material distributed over the tubular member such that the pores are substantially free of webs formed by the material such that webs are present at fewer than 5% of the crossing points;

wherein the tubular member exhibits a weight gain in each of four longitudinal sections of the tubular member compared to an identical, uncoated tubular member, and

wherein the weight gain varies by no more than 5 percentage points between the largest and smallest gains among the four longitudinal sections.

2. The medical device of claim 1, wherein the weight gain varies by no more than 2.5 percentage points between the largest and the smallest gains among the four sections.

3. The medical device of claim 1, wherein the pores have an average pore size that is less than or equal to about 500 microns when the member is in an expanded state.

4. The medical device of claim 1, wherein the pores have an average pore size that is less than or equal to about 320 microns when the member is in an expanded state.

5. The medical device of claim 3, wherein the pores have an average pore size that is measured using an inscribed circle diameter.

6. The medical device of claim 1, wherein the tubular member has a porosity that is greater than or equal to about 50% and less than or equal to about 85% when the member is in an expanded state.

7. The medical device of claim 1, wherein the distribution of the antithrombogenic material is substantially complete over the tubular member.

8. The medical device of claim 1, wherein the distribution of the antithrombogenic material is substantially complete over at least a circumferential section of the tubular member that is 5 mm or more in length.

9. The medical device of claim 8, wherein the antithrombogenic material comprises an anti-thrombogenic polymer.

10. The medical device of claim 9, wherein the antithrombogenic polymer comprises 2-Methacryloyloxyethyl phosphorylcholine.

11. A medical device for treating an aneurysm, comprising:

a tubular body configured to be implanted in a blood vessel and comprising a plurality of braided filaments, the body being expandable to an expanded state for treatment of the aneurysm, the body having a first section for spanning the neck of the aneurysm and a plurality of pores located between the filaments, each of the filaments crossing another of the filaments at a respective crossing point; and

the first section having a substantially complete distribution of antithrombogenic material over the filaments;

wherein the first section is substantially free of webs formed by the antithrombogenic material such that webs are present at fewer than 5% of the crossing points,

wherein the first section of the tubular body exhibits a weight gain in each of four longitudinal sections of the first section of the tubular body compared to an identical, uncoated tubular body, and

wherein the weight gain varies by no more than 5 percentage points between the largest and smallest gains among the four longitudinal sections.

12. The medical device of claim 11, wherein the weight gain varies by no more than 2.5 percentage points between the largest and the smallest gains among the four longitudinal sections.

13. The medical device of claim 11, wherein the pores have an average pore size that is less than or equal to about 500 microns when the body is in the expanded state.

14. The medical device of claim 11, wherein the pores have an average pore size that is less than or equal to about 320 microns when the body is in the expanded state.

15. The medical device of claim 13, wherein the pores have an average pore size that is measured using an inscribed circle diameter.

16. The medical device of claim 11, wherein the first section has a porosity that is greater than or equal to about 50% and less than or equal to about 85% when the body is in the expanded state.

17. The medical device of claim 11, wherein the first section comprises less than an entire length of the tube.

18. The medical device of claim 11, wherein the distribution of the antithrombogenic material is substantially complete over at least a circumferential section of the first section that is 5 mm or more in length.

19. The medical device of claim 18, wherein the antithrombogenic material comprises an anti-thrombogenic polymer.

20. The medical device of claim 19, wherein the antithrombogenic polymer comprises 2-Methacryloyloxyethyl phosphorylcholine.