Methods and compositions for preventing opioid abuse

• US 10,695,342 B2
• Filed: 02/13/2017
• Issued: 06/30/2020
• Est. Priority Date: 04/27/2015
• Status: Active Grant

• Current Assignee: 3St Research LLC, Albany Molecular Research Incorporated
• Original Assignee: Albany Molecular Research Incorporated
• Inventors: Surman, Matthew, Thottathil, John K., Golden, Kathryn, Pasetto, Paolo, Jin, Xiaomin, Jiang, Xiaowu, Camara, Fatoumata
• Primary Examiner(s): Bakshi, Pancham
• Application Number:
  US15/431,572
• Publication Number:
  US 20170157116A1
• Time in Patent Office: 1,233 Days
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 47/542 Carboxylic acids, e.g. a fatty acid or an amino acid
• CPC Class Codes: C07D 489/08 Oxygen atom

Abstract

Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.

Claims

1. An abuse-resistant opioid compound selected from the group consisting of:

2. The abuse-resistant opioid compound of claim 1 having the formula:

3. The abuse-resistant opioid compound of claim 1 having the formula: