Device and method for providing phototherapy to the heart

• US 10,695,577 B2
• Filed: 04/06/2004
• Issued: 06/30/2020
• Est. Priority Date: 12/21/2001
• Status: Expired due to Term

• Current Assignee: PhotoThera, Inc.
• Original Assignee: PhotoThera, Inc.
• Inventors: De Taboada, Luis, Streeter, Jackson
• Primary Examiner(s): Flory, Christopher A
• Assistant Examiner(s): Huh, Vynn V
• Application Number:
  US10/818,947
• Publication Number:
  US 20040260367A1
• Time in Patent Office: 5,929 Days
• Field of Search: 128898, 607 88- 93, 606 3, 606 9- 15, 606192-194, 600428
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/067 using laser light

Abstract

A method for treating a patient'"'"'s heart is provided. The method includes providing a light source which emits light having an initial power density. The method further includes positioning the light source relative to the patient'"'"'s heart with intervening tissue of the patient between the light source and the patient'"'"'s heart. The method further includes directing light onto cardiac tissue of the patient'"'"'s heart from the light source through the intervening tissue without damaging the intervening tissue. The cardiac tissue is irradiated by an efficacious power density of light for an efficacious period of time.

Claims

1. A method of treating a patient'"'"'s heart, the method comprising:

providing a therapy apparatus that emits light having a controllably variable power density, the therapy apparatus comprising a plurality of light sources and defining two or more groups of the light sources, each of the defined groups of the light sources comprising two or more of the light sources from the plurality of light sources that are configured to be selectively activated together as a group;

positioning the therapy apparatus relative to the patient'"'"'s heart with intervening tissue including lung tissue of the patient between the plurality of light sources and the patient'"'"'s heart; and

selectively activating two or more of the groups of the light sources in manners that differ in comparison to each other and directing light emitted from the two or more of the groups of the light sources onto cardiac tissue of the patient'"'"'s heart through the intervening tissue without damaging the intervening tissue, wherein the light emitted from the two or more groups of the light sources is simultaneously activated during the patient'"'"'s breathing cycle to provide a therapy pattern, and wherein the light is directed onto the cardiac tissue during selected portions of the patient'"'"'s breathing cycle during which a percentage of the intervening lung tissue is at a minimum.

2. The method of claim 1, wherein the two or more of the groups of the light sources emit light having an initial power density of at least 10 mW/cm² during the selected portions of the patient'"'"'s breathing cycle.

3. The method of claim 1, wherein the two or more of the groups of the light sources emit light having an initial power density between 10 mW/cm² and 10 W/cm² during the selected portions of the patient'"'"'s breathing cycle.

4. The method of claim 1, wherein the light has a wavelength between 590 nanometers and 3000 nanometers.

5. The method of claim 1, wherein the light has a wavelength between 780 nanometers and 1064 nanometers.

6. The method of claim 1, wherein the light has a wavelength between 780 nanometers and 840 nanometers.

7. The method of claim 1, wherein the light comprises a first wavelength and light having a second wavelength, the light having the first wavelength being transmitted concurrently with the light having the second wavelength to the cardiac tissue.

8. The method of claim 1, wherein the light emitted by the two or more of the groups of the light sources is pulsed.

9. The method of claim 1, wherein positioning the plurality of light sources comprises placing the plurality of light sources outside the patient'"'"'s torso and interposing an element between the plurality of light sources and the torso, the element inhibiting temperature increases at the torso due to the light.

10. The method of claim 1, wherein positioning the therapy apparatus comprises placing the therapy apparatus on the patient'"'"'s skin surface.

11. The method of claim 1, wherein the plurality of light sources comprises at least one needle which provides a conduit for the light from the plurality of light sources, and positioning the plurality of light sources comprises inserting the at least one needle through at least a portion of the skin of the patient'"'"'s torso.

12. The method of claim 1, further comprising directing the light onto the cardiac tissue for at least one treatment period of at least ten minutes.

13. The method of claim 1, further comprising directing the light onto the cardiac tissue for at least one treatment period of at least five minutes.

14. The method of claim 1, further comprising directing the light onto the cardiac tissue for a first treatment period and for a second treatment period commenced subsequent to the completion of the first treatment period.

15. The method of claim 14, wherein commencement of the second treatment period occurs at least five minutes after completion of the first treatment period.

16. The method of claim 14, wherein commencement of the second treatment period occurs at least one week after completion of the first treatment period.

17. The method of claim 1, wherein the directing light onto the cardiac tissue comprises pulsing the light such that the light is directed onto the cardiac tissue only during the selected portions of the patient'"'"'s breathing cycle during which the percentage of the intervening lung tissue is at the minimum.

18. The method of claim 1, wherein the cardiac tissue is irradiated by an average power density of at least 0.01 mW/cm² during the selected portions of the patient'"'"'s breathing cycle.

19. A method for treating a patient'"'"'s heart, the method comprising:

introducing light onto a target area of the heart by directing the light having a controllably variable power density through intervening tissue of the patient without damaging the intervening tissue,

wherein the light is from a therapy apparatus comprising a plurality of light sources and defining two or more groups of the light sources, each of the defined groups of the light sources comprising two or more of the light sources from the plurality of light sources that are configured to be selectively activated together as a group,

wherein the light emitted from the two or more groups of the light sources is simultaneously activated during the patient'"'"'s breathing cycle to provide a therapy pattern such that the light impinges onto the target area during selected portions of the patient'"'"'s breathing cycle, and

wherein the light is introduced from the plurality of light sources positioned within the patient'"'"'s esophagus.

20. The method of claim 19, wherein the light comprises a first wavelength and light having a second wavelength, the light having the first wavelength being transmitted sequentially with the light having the second wavelength to the target area of the heart.

21. The method of claim 19, further comprising determining the initial power density to be introduced so as to deliver the efficacious power density onto the target area, said determining based on at least one characteristic indicative of attenuation of light by the intervening tissue.

22. The method of claim 21, wherein the characteristic is selected from a group consisting of:

skin pigmentation, presence and color of hair over the target area, amount of fat tissue, body size, breast size, presence of bruised or scarred tissue, amount of pericardial fluid, presence of other materials within the intervening tissue, and the location of the target area of the heart.

23. The method of claim 19, wherein the directing light comprises pulsing the light such that the light is directed onto the cardiac tissue only during the selected portions of the patient'"'"'s breathing cycle during which lung tissue comprises a minimum fraction of the intervening tissue.

24. The method of claim 19, wherein the light has an initial power density of at least 10 mW/cm² during the selected portions of the patient'"'"'s breathing cycle.

25. The method of claim 19, wherein the light has an initial power density between 10 mW/cm² and 10 W/cm² during the selected portions of the patient'"'"'s breathing cycle.

26. The method of claim 19, wherein the target area is irradiated by an average power density of at least 0.01 mW/cm² during the selected portions of the patient'"'"'s breathing cycle.

27. A method of treating a patient'"'"'s heart, the method comprising:

positioning a therapy apparatus comprising a plurality of light sources and defining two or more groups of the light sources, each of the defined groups of the light sources comprising two or more of the light sources from the plurality of light sources that are configured to be selectively activated together as a group, the groups of the light sources having a controllably variable power density relative to the patient'"'"'s heart with intervening tissue including lungs of the patient between the plurality of light sources and the patient'"'"'s heart; and

directing light onto cardiac tissue of the patient'"'"'s heart from the plurality of light sources through the intervening tissue without damaging the intervening tissue, the light emitted from the two or more groups of the light sources being simultaneously activated during the patient'"'"'s breathing cycle to provide a therapy pattern during selected portions of the patient'"'"'s breathing cycle during which a percentage of the intervening lung tissue is at a minimum.

28. The method of claim 27, wherein the cardiac tissue is irradiated by an average power density of light of at least 0.01 mW/cm².

29. The method of claim 27, wherein the directing light onto the cardiac tissue comprises pulsing the light such that the light is directed onto the cardiac tissue only during the selected portions of the patient'"'"'s breathing cycle during which the percentage of the intervening lung tissue is at the minimum.

30. The method of claim 27, wherein the light source emits light having an initial power density of at least 10 mW/cm² during the selected portions of the patient'"'"'s breathing cycle.

31. The method of claim 27, wherein the light source emits light having an initial power density between 10 mW/cm² and 10 W/cm² during the selected portions of the patient'"'"'s breathing cycle.