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Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG

  • US 10,696,966 B2
  • Filed: 10/26/2015
  • Issued: 06/30/2020
  • Est. Priority Date: 01/11/2010
  • Status: Active Grant
First Claim
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1. A synthetic, modified single-stranded oligonucleotide of 20 to 21 nucleotides in length comprising at least one modification wherein the at least one modification is selected from:

  • at least one modified sugar moiety;

    at least one modified internucleotide linkage;

    at least one modified nucleotide, and combinations thereof;

    wherein said oligonucleotide is an antisense compound which is 100% complementary to and specifically hybridizes to a natural antisense polynucleotide of a Sex Hormone Binding Globulin (SHBG) gene selected from SEQ ID NO;

    2 or to a target region from nucleotides 1 to 831 of SEQ ID NO;

    3 and upregulates the function and/or expression of a Sex Hormone Binding Globulin (SHBG) gene in vivo or in vitro as compared to a normal control.

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