Ocular implant delivery system and method

• US 10,709,547 B2
• Filed: 07/14/2015
• Issued: 07/14/2020
• Est. Priority Date: 07/14/2014
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Ivantis Inc. (Alcon Incorporated)
• Inventors: Schieber, Andrew T.
• Primary Examiner(s): Yabut, Diane D
• Application Number:
  US15/325,628
• Publication Number:
  US 20170156848A1
• Time in Patent Office: 1,827 Days
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61F 2/148 Implantation instruments specially adapted therefor
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

A method and system for deploying an ocular implant into Schlemm'"'"'s canal of an eye. The method includes the steps of inserting a distal end of a cannula through a cornea of the eye and into an anterior chamber of the eye, the cannula having a distal opening extending from the distal end and through a side wall, a curved distal portion and a curved intermediate portion; placing the distal opening of the cannula into fluid communication with Schlemm'"'"'s canal; advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches the cannula distal opening.

Claims

1. A system for delivering an ocular implant into Schlemm'"'"'s canal through an incision associated with cataract surgery, the system comprising:

a cannula defining a central axis and a passageway extending from a proximal end to a distal end along the central axis, the cannula having a distal opening extending through a side wall and the distal end of the cannula to form a trough, a curved distal portion, a curved intermediate portion, and a proximal portion;

an ocular implant disposed within the passageway of the cannula; and

a delivery tool having a distal interlocking portion engaging a complementary interlocking portion of the ocular implant; and

wherein the intermediate portion of the cannula has a first radius of curvature along the central axis and the distal portion has a second radius of curvature along the central axis, the first radius of curvature being greater than the second radius of curvature to allow for substantially tangential entry of the cannula into Schlemm'"'"'s canal through the incision.

2. The system of claim 1, wherein the intermediate portion of the cannula extends distally from a first point distal to the proximal end to a second point proximal to the distal end and the distal portion extends distally from the second point to the distal end.

3. The system of claim 1, wherein the distal interlocking portion of the delivery tool and the complementary interlocking portion of the ocular implant form a mechanically interlocking connection when the interlocking portion of the delivery tool is proximal to the trough portion of the cannula.

4. The system of claim 1, wherein the distal interlocking portion of the delivery tool has an at-rest shape different from the shape of the cannula, the cannula side wall preventing the delivery tool from assuming its at-rest shape when the interlocking portion of the delivery tool is proximal to the trough of the cannula.

5. The system of claim 4, wherein the delivery tool at-rest shape is a curve having a smaller radius of curvature than the second radius of curvature of the cannula.

6. The system of claim 1, wherein an angle between a line tangential to the distal end of the cannula and the central axis of the proximal portion of the cannula is in the range of 90°

to 165°

.

7. A cannula for delivering an ocular implant into Schlemm'"'"'s canal of an eye through an incision associated with cataract surgery, the cannula comprising:

a tubular member having a central axis and a side wall and extending from a proximal end to a distal end, the tubular member comprising;

a passageway extending from the proximal end to the distal end of the tubular member along the central axis;

a generally straight proximal portion extending distally from the proximal end to a first point;

a curved intermediate portion extending distally from the first point to a second point proximal to the distal end;

a curved distal portion extending distally from the second point to the distal end; and

a distal opening extending through the side wall and the distal end of the cannula to form a trough; and

wherein the intermediate portion of the cannula has a first radius of curvature along the central axis and the distal portion has a second radius of curvature along the central axis and the first radius of curvature is greater than the second radius of curvature to allow for substantially tangential entry of the cannula into Schlemm'"'"'s canal through the incision.

8. The cannula of claim 7, wherein the passageway is configured to receive the ocular implant.

9. A method of deploying an ocular implant into Schlemm'"'"'s canal of an eye, comprising:

inserting a distal end of a cannula through an incision optimized for cataract surgery in a cornea of the eye and into an anterior chamber of the eye, the cannula comprising a central axis and a passageway extending from a proximal end to a distal end along the central axis, the cannula further comprising a distal opening extending through a side wall and the distal end of the cannula to form a trough, a curved distal portion, a curved intermediate portion, and a proximal portion, wherein the curved intermediate portion of the cannula has a first radius of curvature along the central axis and the distal curved portion has a second radius of curvature along the central axis different than the first radius of curvature;

placing the distal opening of the cannula into fluid communication with Schlemm'"'"'s canal;

advancing an ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and

disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches distal opening of the cannula.

10. The method of claim 9, wherein the intermediate portion of the cannula extends distally from a first point distal to the proximal end to a second point proximal to the distal end and the distal portion extends distally from the second point to the distal end.

11. The method of claim 9, wherein the first radius of curvature is greater than the second radius of curvature.

12. The method of claim 9, wherein the disengaging step comprises separating the distal portion of the delivery tool and the ocular implant from each other when the distal portion of the delivery tool passes through the distal opening of the cannula.

13. The method of claim 12, wherein the separating step is performed before the distal portion of the delivery tool reaches the distal end of the cannula.

14. The method of claim 12, wherein the separating step comprises maintaining contact between the ocular implant and the cannula and moving the distal portion of the delivery tool away from the cannula.

15. The method of claim 14, wherein the distal portion of the delivery tool has an at-rest shape, the separating step further comprising permitting the distal portion of the delivery tool to assume its at-rest shape.

16. The method of claim 15, wherein the at-rest shape is a curve having a smaller radius of curvature than the second radius of curvature of the cannula.

17. A method of deploying an ocular implant into Schlemm'"'"'s canal of an eye, comprising:

inserting a distal end of a cannula through an incision in the eye and into an anterior chamber of the eye, wherein a location of the incision is optimized for a cataract surgery, the cannula comprising a central axis and a passageway extending from a proximal end to a distal end along the central axis, the cannula further comprising a distal opening extending through a side wall and the distal end of the cannula to form a trough, a curved distal portion, a curved intermediate portion, and a proximal portion, wherein the curved intermediate portion of the cannula has a first radius of curvature along the central axis and the curved distal portion has a second radius of curvature along the central axis different than the first radius of curvature;

placing the distal opening of the cannula into fluid communication with Schlemm'"'"'s canal such that the cannula enters Schlemm'"'"'s canal in a substantially tangential orientation;

advancing an ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and

disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches distal opening of the cannula.

18. The method of claim 17, wherein the intermediate portion of the cannula extends distally from a first point distal to the proximal end to a second point proximal to the distal end and the distal portion extends distally from the second point to the distal end.

19. The method of claim 17, wherein the first radius of curvature is greater than the second radius of curvature.

20. The method of claim 17, wherein the disengaging step comprises separating the distal portion of the delivery tool and the ocular implant from each other when the distal portion of the delivery tool passes through the distal opening of the cannula.

21. The method of claim 20, wherein the separating step is performed before the distal portion of the delivery tool reaches the distal end of the cannula.

22. The method of claim 20, wherein the separating step comprises maintaining contact between the ocular implant and the cannula and moving the distal portion of the delivery tool away from the cannula.

23. The method of claim 22, wherein the distal portion of the delivery tool has an at-rest shape, the separating step further comprising permitting the distal portion of the delivery tool to assume its at-rest shape.

24. The method of claim 23, wherein the at-rest shape is a curve having a smaller radius of curvature than the second radius of curvature of the cannula.