Biocompatible and bioabsorbable derivatized chitosan compositions
First Claim
1. A biocompatible, bioabsorbable, deacetylated and reacetylated reduced amine functionality chitosan composition having a degree of N-deacetylation of between about 15% and 40% and an acid content between about 2% (w/w) and 8% (w/w).
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Abstract
The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
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Citations
17 Claims
- 1. A biocompatible, bioabsorbable, deacetylated and reacetylated reduced amine functionality chitosan composition having a degree of N-deacetylation of between about 15% and 40% and an acid content between about 2% (w/w) and 8% (w/w).
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11. A method of making a biocompatible, bioabsorbable chitosan composition comprising:
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obtaining deacetylated chitosan; producing reacetylated chitosan having a molecular weight of at least about 90 kDa to about 170 kDa from the deacetylated chitosan having a degree of N-deacetylation of between about 15% and 40%; and resolubilizing the reacetylated chitosan to aqueous solution using carbonic acid. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification