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Microfluidic valve and method of making same

  • US 10,710,069 B2
  • Filed: 06/27/2014
  • Issued: 07/14/2020
  • Est. Priority Date: 11/14/2006
  • Status: Active Grant
First Claim
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1. A method of making a microfluidic valve in a microfluidic device comprising a reactor and a window disposed relative to the reactor to allow detection of fluorescence from the reactor, the method of making comprising:

  • directing a dispensing head over an inlet hole in a microfluidic substrate of the microfluidic device;

    propelling a quantity of thermally responsive substance as a succession of fluid dots from the dispensing head into the inlet hole; and

    maintaining a temperature of the microfluidic substrate so that the thermally responsive substance flows by capillary action from the inlet hole into a microfluidic loading channel in communication with the inlet hole, the microfluidic loading channel comprising a first end and a second end, the second end of the microfluidic loading channel intersecting a microfluidic flow channel at a T-junction such that the flow of thermally responsive substance stops when the thermally responsive substance reaches the microfluidic flow channel without entering the microfluidic flow channel to form the microfluidic valve.

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