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Mixed-phase fluids for nucleic acid sequencing and other analytical assays

  • US 10,710,076 B2
  • Filed: 12/02/2019
  • Issued: 07/14/2020
  • Est. Priority Date: 12/04/2018
  • Status: Active Grant
First Claim
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1. A method for sequencing a nucleic acid, comprising(a) providing a sequencing system comprising(i) a flow cell comprising a nucleic acid immobilized therein,(ii) a bubble generator component that delivers gas bubbles to a liquid at a predefined rate, wherein the bubble generator component comprises a filter membrane located at a junction through which the gas is delivered to the liquid;

  • (b) delivering a series of fluids to the inside of the flow cell to perform a cycle of a sequencing process, wherein at least one of the fluids is a fluid foam produced by the bubble generator component comprising gas bubbles in the liquid; and

    (c) repeating step (b), thereby determining the sequence for the nucleic acid.

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