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Compositions for pulmonary delivery of long-acting muscarinic antagonists or long-acting B2 adrenergic receptor agonists and associated methods and systems

  • US 10,716,753 B2
  • Filed: 11/02/2018
  • Issued: 07/21/2020
  • Est. Priority Date: 05/29/2009
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition deliverable from a metered dose inhaler, comprising:

  • a suspension medium comprising a pharmaceutically acceptable propellant;

    a plurality of active agent particles comprising a long-acting muscarinic antagonist (LAMA) active agent or a long-acting β

    2 adrenergic receptor agonist (LABA) active agent; and

    a plurality of respirable suspending particles, wherein the respirable suspending particles are formed separately from and are different particles than the active agent particles and are formed of a dry particulate phospholipid material that is substantially insoluble in the suspension medium;

    and wherein the ratio of the total mass of the respirable suspending particles to the total mass of the active agent particles is from greater than 1;

    1 up to 200;

    1.

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