Methods and systems for treatment of acute ischemic stroke

• US 10,722,251 B2
• Filed: 08/30/2018
• Issued: 07/28/2020
• Est. Priority Date: 08/05/2011
• Status: Active Grant

• Current Assignee: Route 92 Medical, Inc.
• Original Assignee: Route 92 Medical, Inc.
• Inventors: Garrison, Michi E., Chou, Tony M.
• Primary Examiner(s): Mensh, Andrew J
• Application Number:
  US16/117,741
• Publication Number:
  US 20190008534A1
• Time in Patent Office: 698 Days
• Field of Search: 604 8, 604 9, 604508, 604509, 604523
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/32037 for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22039 eccentric
• CPC Class Codes: A61B 2017/22044 with a pointed tip
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/22094 for crossing total occlusions, i.e. piercing
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2017/2217 single wire changing shape to a gripping configuration
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/82 Membrane pumps, e.g. bulbs
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0169 Exchanging a catheter while keeping the guidewire in place
• CPC Class Codes: A61M 25/0662 Guide tubes
• CPC Class Codes: A61M 60/43 using vacuum at the blood pump, e.g. to accelerate filling

Abstract

Described are systems for performing a medical procedure at a treatment site in a cerebral vessel of a patient. The system includes a catheter and an inner member sized to slide within the catheter lumen. The inner member defines a single lumen and has a distal portion and a distal-most end having a distal opening, the distal portion having a first outer diameter that tapers distally to a second outer diameter that is smaller than the first outer diameter. A flexibility of the distal portion decreases smoothly from a flexibility at the second outer diameter to a flexibility at the first outer diameter when the system is in an advancement configuration. The system is sufficiently flexible that, when in the advancement configuration, the system is configured to be advanced distal to a petrous portion of an internal carotid artery.

Claims

1. A system of devices for performing a medical procedure at a treatment site in a cerebral vessel of a patient, the system comprising:

a catheter having a catheter lumen having an inner diameter and a distal end; and

an inner member sized to slide within the catheter lumen, wherein the inner member defines a single lumen and has a distal portion and a distal-most end having a distal opening, the distal portion having a first outer diameter that tapers distally to a second outer diameter that is smaller than the first outer diameter, wherein the inner member transitions in flexibility from a proximal end of the inner member to the distal-most end of the inner member, the distal-most end of the inner member being more flexible than the distal end of the catheter, and

wherein the system is in an advancement configuration when the inner member is positioned coaxially in the catheter lumen with the distal portion positioned distal to the distal end of the catheter and the inner member held fixed relative to the catheter,

wherein a flexibility of the distal portion decreases smoothly from a flexibility at the second outer diameter to a flexibility at the first outer diameter when the system is in the advancement configuration, and

wherein the system of devices is sufficiently flexible that, when the system is in the advancement configuration, the catheter and the inner member are configured to be concurrently advanced distal to a petrous portion of an internal carotid artery while the system of devices is positioned in the advancement configuration.

2. The system of claim 1, wherein a stent retriever is positioned within the single lumen of the inner member.

3. The system of claim 1, wherein the inner member at the second outer diameter is constructed of a material that is softer than a material at the first outer diameter.

4. The system of claim 1, wherein, when the system of devices is positioned in the advancement configuration, a flexibility of the distal portion of the inner member decreases proximally and creates a smooth transition in flexibility from the second outer diameter to the distal end of the catheter.

5. The system of claim 4, wherein a stent retriever is positioned within the single lumen of the inner member.

6. The system of claim 4, wherein the first outer diameter substantially corresponds to the inner diameter of the distal end of the catheter.

7. The system of claim 1, wherein the inner member further comprises a flexible tubular extension extending distally past the distal portion, wherein a length of the tubular extension has a uniform outer diameter and wherein the distal opening is at the distal-most end of the tubular extension.

8. The system of claim 7, wherein the uniform outer diameter of the tubular extension and the second outer diameter of the distal portion substantially correspond.

9. The system of claim 7, wherein a stent retriever is positioned within the single lumen of the inner member.

10. The system of claim 1, wherein, when the system of devices is positioned in the advancement configuration and a guidewire is positioned within the single lumen and extended out the distal opening, the inner member creates a smooth transition from an outer diameter of the guidewire to an inner diameter at the distal end of the catheter.

11. The system of claim 10, wherein a flexibility of the inner member creates a smooth transition in flexibility between a flexibility of the guidewire to a flexibility of the distal end of the catheter.

12. The system of claim 1, wherein, when the system of devices is positioned in the advancement configuration and a guidewire is positioned within the single lumen and extended out the distal opening, a flexibility of the inner member creates a smooth transition in flexibility between a flexibility of the guidewire to a flexibility of the distal end of the catheter.

13. The system of claim 1, wherein the catheter further comprises a flexible distal luminal portion and a proximal tether element extending proximally from a point of attachment near a proximal end of the flexible distal luminal portion, the proximal tether element extending proximally to outside the body of the patient.

14. The system of claim 13, wherein an outer diameter of the proximal tether element at the point of attachment is smaller than an outer diameter of the distal luminal portion at the point of attachment.

15. The system of claim 13, wherein the proximal tether element is solid or has a lumen.

16. The system of claim 13, further comprising a second catheter having a catheter lumen having an inner diameter and a distal end, wherein the inner diameter of the catheter lumen of the second catheter is sized to slidably receive the catheter therein.

17. The system of claim 16, wherein the second catheter further comprises a flexible distal luminal portion and a proximal tether element extending proximally from a point of attachment near a proximal end of the flexible distal luminal portion, the proximal tether element of the second catheter extending proximally to outside the body of the patient.

18. The system of claim 17, wherein an outer diameter of the proximal tether element of the second catheter at the point of attachment is smaller than an outer diameter of the distal luminal portion of the second catheter at the point of attachment.

19. The system of claim 18, wherein the proximal tether element of the second catheter is solid or has a lumen.