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Oligonucleotide compositions and methods thereof

  • US 10,724,035 B2
  • Filed: 05/03/2017
  • Issued: 07/28/2020
  • Est. Priority Date: 05/04/2016
  • Status: Active Grant
First Claim
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1. An oligonucleotide having the structure of:

  • mG * SmUmGmCmA * SC * SA * SC * SA * SG * ST * SA * SG * RA * ST * SmGmAmGmG * SmG (SEQ ID NO;

         1467), or a pharmaceutically acceptable salt thereof, wherein;

    *S represents a Sp phosphorothioate;

    *R represents a Rp phosphorothioate; and

    m represents a 2′

    -OMe modification to a nucleoside.

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