Device for treating glaucoma

• US 10,729,583 B2
• Filed: 07/30/2018
• Issued: 08/04/2020
• Est. Priority Date: 01/12/2012
• Status: Active Grant

• Current Assignee: InnFocus, Inc. (Santen Pharmaceutical Company Limited)
• Original Assignee: InnFocus, Inc. (Santen Pharmaceutical Company Limited)
• Inventors: Pinchuk, Leonard
• Primary Examiner(s): Weng, Kai H
• Application Number:
  US16/049,432
• Publication Number:
  US 20180344526A1
• Time in Patent Office: 736 Days
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00736 Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments A61F9/008 takes precedence
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202

Abstract

An implantable device for treatment of glaucoma of the eye. In one aspect, the device includes an elongate duct for diverting aqueous humor from the anterior chamber of the eye, the elongate duct having a central axis with a proximal end and distal end opposite one another. A least one element is spaced apart from the proximal end and the distal end of said elongate duct and extends radially outward beyond an outer surface of said elongate duct in at least two directions transverse to the central axis of said elongate duct, wherein the at least one element has a distal portion with a tapered profile facing the distal end of said elongate duct. The at least one element is configured to deform in a tissue passage leading into the anterior chamber of the eye as it is inserted into the tissue passage in response to forces applied by surrounding ocular tissue of the tissue passage. Other aspects are also described and claimed.

Claims

1. An implantable device for treatment of glaucoma of the eye, the implantable device comprising:

an elongate duct for diverting aqueous humor from the anterior chamber of the eye, said elongate duct having a central longitudinal axis with a proximal end and distal end opposite one another; and

at least one element spaced apart from the proximal end and the distal end of said elongate duct and extending radially outward beyond an outer surface of said elongate duct in at least two directions transverse to the central longitudinal axis of said elongate duct to respective outer edges, wherein each outer edge has a first portion having a tapered profile facing the distal end of said elongate duct, and has a second portion at a maximal radial offset with respect to the central longitudinal axis, the second portion of said outer edges defining a maximal cross-sectional dimension of the device, and wherein the first and second portions of each outer edge extend longitudinally relative to the central longitudinal axis of said elongate duct;

wherein said at least one element is configured to deform in a tissue passage leading into the anterior chamber of the eye as it is inserted into the tissue passage in response to forces applied by surrounding ocular tissue of the tissue passage, and wherein said outer edges of said at least one element are configured to contact and form a seal with ocular tissue that surrounds the at least one element.

2. An implantable device according to claim 1, wherein:

said at least one element extends radially outward beyond the outer surface of said elongate duct in at least two opposed directions transverse to the central longitudinal axis of said elongate duct.

3. An implantable device according to claim 1, wherein:

said at least one element has a circular cross-section in a direction transverse to the central longitudinal axis of said elongate duct; and

/or

said at least one element has a rhomboid cross-section in a direction transverse to the central longitudinal axis of said elongate duct; and

/or

said at least one element has an oblong cross-section in a direction transverse to the central longitudinal axis of said elongate duct; and

/or

said at least one element has an ovoid cross-section in a direction transverse to the central longitudinal axis of said elongate duct.

4. An implantable device according to claim 1, wherein:

said at least one element and said elongate duct have different hardnesses.

5. An implantable device according to claim 1, wherein:

said at least one element includes first and second tabs that extend radially outward beyond an outer surface of said elongate duct on opposite sides of said elongate duct to respective outer edges, wherein said first and second tabs each have a distal surface having a tapered profile facing the distal end of said elongate duct.

6. An implantable device according to claim 5, wherein:

said first and second tabs have a hardness different from said elongate duct.

7. An implantable device according to claim 5, wherein:

said first and second tabs are configured to deform in a tissue passage leading into the anterior chamber of the eye as it is inserted into the passage in response to forces applied by surrounding ocular tissue of the tissue passage.

8. An implantable device according to claim 5, wherein:

said first and second tabs each have a hardness within the range between Shore 30 A and Shore 80 A.

9. An implantable device according to claim 5, wherein:

said outer edges of said first and second tabs are blunt.

10. An implantable device according to claim 1, wherein:

the elongate duct has a maximal cross-sectional dimension no more than 0.4 mm; and

a maximal cross-sectional dimension of the device defined by the outer edges is at least 0.9 mm.

11. An implantable device according to claim 1, wherein:

the elongate duct has a proximal portion defining a cylindrical outer surface and a distal portion defining a cylindrical outer surface; and

said at least one element includes first and second tabs disposed intermediate the cylindrical outer surfaces of said proximal and distal portions of said elongate duct.

12. An implantable device according to claim 11, wherein:

the first and second tabs are generally planar in form and extend in a common plane radially outward beyond the cylindrical outer surfaces of said proximal and distal portions of said elongate duct to respective outer edges having tapered first portions that extend radially and longitudinally with respect to the central longitudinal axis and face the distal end of said elongate duct.

13. An implantable device according to claim 11, wherein:

said second portion of said outer edge of said first tab is a first blunt outer surface, said second portion of said outer edge of said second tab is a second blunt outer surface, wherein said maximal cross-sectional dimension of the device is defined by maximal distance between the first blunt outer surface and the second blunt outer surface.

14. An implantable device according to claim 1, wherein:

the at least one element is part of a wedge-shaped body extending radially and longitudinally to the respective outer edges having tapered first portions that extend radially and longitudinally with respect to the central longitudinal axis and face the distal end of said elongate duct.

15. An implantable device according to claim 12, wherein:

the distal end of the elongate duct has a tapered profile.

16. An implantable device for treatment of glaucoma of the eye, the implantable device consisting of:

an elongate duct for diverting aqueous humor from the anterior chamber of the eye, said elongate duct having a central longitudinal axis with a proximal end and distal end opposite one another; and

at least one element spaced apart from the proximal end and the distal end of said elongate duct and extending radially outward beyond an outer surface of said elongate duct in at least two directions transverse to the central longitudinal axis of said elongate duct to respective outer edges, wherein said at least one element has a distal portion with a tapered profile facing the distal end of said elongate duct,

wherein said at least one element is configured to deform in a tissue passage leading into the anterior chamber of the eye as it is inserted into the tissue passage in response to forces applied by surrounding ocular tissue of the tissue passage, and wherein said outer edges of said at least one element are configured to contact and form a seal with ocular tissue that surrounds the at least one element, and

wherein each outer edge has a first portion having a tapered profile facing the distal end of said elongate duct, and has a second portion at a maximal radial offset with respect to the central longitudinal axis, the second portion of said outer edges defining a maximal cross-sectional dimension of the device, and wherein the first and second portions of each outer edge extend longitudinally relative to the central longitudinal axis of said elongate duct.

17. An implantable device according to claim 16, wherein:

the at least one element is part of a wedge-shaped body extending radially and longitudinally to the respective outer edges having tapered first portions that extend radially and longitudinally with respect to the central longitudinal axis and face the distal end of said elongate duct.

18. An implantable device according to claim 16, wherein:

the at least one element includes first and second tabs that are generally planar in form and extend in a common plane radially outward beyond cylindrical outer surfaces of said proximal and distal portions of said elongate duct to the respective outer edges having tapered first portions that extend radially and longitudinally with respect to the central longitudinal axis and face the distal end of said elongate duct.

19. An implantable device according to claim 18, wherein:

the distal end of the elongate duct has a tapered profile.