Systemic delivery of myostatin short interfering nucleic acids (siNA) conjugated to a lipophilic moiety
First Claim
1. A double-stranded short interfering nucleic acid (siNA) molecule that inhibits the expression of myostatin, wherein:
- (a) the siNA molecule comprises a sense strand and an antisense strand;
(b) each strand is independently 19 to 30 nucleotides in length; and
(c) the antisense strand comprises the nucleotide sequence of;
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Abstract
The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.
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Citations
12 Claims
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1. A double-stranded short interfering nucleic acid (siNA) molecule that inhibits the expression of myostatin, wherein:
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(a) the siNA molecule comprises a sense strand and an antisense strand; (b) each strand is independently 19 to 30 nucleotides in length; and (c) the antisense strand comprises the nucleotide sequence of; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification