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Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis

  • US 10,729,811 B2
  • Filed: 06/04/2018
  • Issued: 08/04/2020
  • Est. Priority Date: 10/22/2012
  • Status: Active Grant
First Claim
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1. An apparatus for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall comprising:

  • a fixative-pretreated bioprosthetic heart valve having one or more cusps, said fixative-pretreated bioprosthetic heart valve mounted on an elastical stent for replacement of a natural diseased valve;

    a coating composition coated on said one or more cusps of the bioprosthetic heart valve after fixation thereof, on said stent or both, wherein said coating composition includes an eNOS activator;

    an anti-proliferative agent for inhibiting cell proliferation;

    an extracellular matrix production inhibitor; and

    an inhibitor of osteoblastogenesis,wherein said coating composition when eluted inhibits stenosis, obstruction and/or calcification of the bioprosthetic heart valve when implanted by preventing the attachment of cKit positive stem cells, SCA1 cells, COP cells, and/or mesenchymal stem cells to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

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