Multi-well rotary synthesizer
First Claim
1. A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:
- a. a first vial and a second vial, wherein the first vial and the second vial are configured for holding the plurality of reagent solutions;
b. means for dispensing configured for dispensing the plurality of reagent solutions into the first and second vials; and
c. means for selectively expelling material from the first and second vials, configured for coupling to the first and second vials and purging material from a selective one of the first vial and the second vial.
2 Assignments
0 Petitions
Accused Products
Abstract
An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The multiple banks of valves provide an additional number of reagent choices while operating in a serial mode and faster reagent distribution while operating in a parallel mode. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain. The cartridge holding the plurality of vials rotates relative to the stationary banks of valves and the waste tube system. The controller rotates the cartridge and operates the banks of valves and the waste tube system in response to the required sequence of dispensing various reagent solutions and flushing appropriate vials in order to form the desired polymer chain within each vial.
110 Citations
34 Claims
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1. A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:
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a. a first vial and a second vial, wherein the first vial and the second vial are configured for holding the plurality of reagent solutions;
b. means for dispensing configured for dispensing the plurality of reagent solutions into the first and second vials; and
c. means for selectively expelling material from the first and second vials, configured for coupling to the first and second vials and purging material from a selective one of the first vial and the second vial. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A synthesizer for forming a polymer chain by sequentially adding monomer units found in a plurality of reagent solutions, the synthesizer comprising:
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a. a first vial configured to hold the plurality of reagent solutions;
b. a second vial configured to hold the plurality of reagent solutions;
c. a cartridge to hold the first vial and the second vial;
d. a dispensing system to dispense the plurality of reagent solutions into the first and second vials; and
e. a purging system to remove material from a selective one of the first vial and the second vial. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. A synthesizer for creating a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:
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a. a plurality of vials wherein each of the plurality of vials is configured to hold material including the plurality of reagent solutions;
b. a cartridge for holding the plurality of vials and dividing the plurality of vials into a first bank of vials including at least one of the plurality of vials and a second bank of vials including at least one of the plurality of vials;
c. a dispensing system configured to sequentially dispense selective ones of the plurality of reagent solutions into the plurality of vials; and
d. a purging system configured to selectively purge material from the first bank of vials and the second bank of vials. - View Dependent Claims (21, 22, 23)
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24. A purging system configured for use with a synthesizer containing a first bank of vials and a second bank of vials wherein the first bank of vials has a first drain and the second bank of vials has a second drain, the purging system comprising:
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a. a pressurizing system for creating a pressure differential within a selective one of the first bank of vials and the second bank of vials; and
b. a first waste tube capable of coupling with a selective one of the first drain to purge material from the first bank of vials and the second drain to purge material from the second bank of vials. - View Dependent Claims (25, 26)
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- 27. A vial comprising a precision bored interior configured to hold a frit for retaining material within the vial above the frit and maintain a consistent flow through the precision bored interior during a flushing procedure.
- 29. A vial comprising an exterior dimension configured to fit within a receiving hole of a cartridge thereby providing a pressure-tight seal between the vial and the cartridge and a precision bored interior to maintain a consistent flow through the precision bored interior during a flushing procedure.
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31. A method of selectively and sequentially dispensing a plurality of reagent solutions to a plurality of vials divided into a first bank of vials and a second bank of vials and selectively purging material from the first bank of vials and the second bank of vials, comprising the steps of:
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a. dispensing one or more of the plurality of reagent solutions to a selective one or more of the plurality of vials; and
b. purging material from a selective one of the first bank of vials and the second bank of vials. - View Dependent Claims (32, 33)
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34. A method of selectively purging material from a selective one of a first vial and a second vial comprising the steps of:
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a. coupling a waste tube to a selective one of a first drain corresponding to the first vial and a second drain corresponding to the second vial; and
b. forming a pressure differential between an interior and an exterior of the selective one of the first vial and the second vial, thereby expelling material from the selective one of the first vial and the second vial through the waste tube.
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Specification