Lyophilization apparatus and methods
First Claim
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1. A bulk lyophilization container comprising:
- a body portion; and
an aseptic closure portion, wherein the body portion is coupled to the aseptic closure portion.
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Accused Products
Abstract
Disclosed are bulk lyophilization containers including aseptic closure portions or heat flux equalization portions that promote improved bulk lyophilization. Also disclosed are methods of using the bulk lyophilization containers and improved lyophilization stoppers.
8 Citations
43 Claims
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1. A bulk lyophilization container comprising:
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a body portion; and
an aseptic closure portion, wherein the body portion is coupled to the aseptic closure portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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- 23. A bulk lyophilization container comprising a heat flux equalizer portion located so as to equalize a heat flux through the bulk lyophilization container.
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28. A method of lyophilization of a product comprising:
increasing uniformity of heat flux to or from the product during any freezing, primary or secondary drying operations that occur during the lyophilization. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
- 37. A lyophilization stopper comprising three or more straight vent notches.
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41. A lyophilization stopper comprising sealing ridges located on an outer surface of the lyophilization stopper.
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42. A lyophilization stopper comprising stopper window vents that penetrate the stopper.
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43. A lyophilization stopper comprising shallow vents that do not penetrate the stopper.
Specification