Signal processing for measurement of physiological analytes
First Claim
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1. A method for continually measuring an analyte present in a biological system, said method comprising:
- (a) transdermally extracting the analyte from the biological system using a sampling system that is in operative contact with a skin or mucosal surface of said biological system;
(b) obtaining a raw signal from the extracted analyte, wherein said raw signal is related to analyte concentration;
(c) subjecting the raw signal obtained in step (b) to a conversion step in order to convert said raw signal to an initial signal output which is indicative of the amount of analyte extracted by the sampling system;
(d) performing a calibration step which converts the initial signal output obtained in step (c) to a measurement value indicative of the concentration of analyte present in the biological system at the time of extraction; and
(e) repeating steps (a)-(c) at least once to obtain a plurality of measurement values, wherein the sampling system is maintained in operative contact with the skin or mucosal surface of said biological system to provide for a continual analyte measurement.
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Abstract
A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
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Citations
44 Claims
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1. A method for continually measuring an analyte present in a biological system, said method comprising:
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(a) transdermally extracting the analyte from the biological system using a sampling system that is in operative contact with a skin or mucosal surface of said biological system;
(b) obtaining a raw signal from the extracted analyte, wherein said raw signal is related to analyte concentration;
(c) subjecting the raw signal obtained in step (b) to a conversion step in order to convert said raw signal to an initial signal output which is indicative of the amount of analyte extracted by the sampling system;
(d) performing a calibration step which converts the initial signal output obtained in step (c) to a measurement value indicative of the concentration of analyte present in the biological system at the time of extraction; and
(e) repeating steps (a)-(c) at least once to obtain a plurality of measurement values, wherein the sampling system is maintained in operative contact with the skin or mucosal surface of said biological system to provide for a continual analyte measurement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A monitoring system for continually or continuously measuring an analyte present in a biological system, said system comprising, in operative combination:
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(a) sampling means for continually or continuously extracting the analyte from the biological system, wherein said sampling means is adapted for extracting the analyte across a skin or mucosal surface of said biological system;
(b) sensing means in operative contact with the analyte extracted by the sampling means, wherein said sensing means obtains a raw signal from the extracted analyte and said raw signal is specifically related to the analyte; and
(c) microprocessor means in operative communication with the sensing means, wherein said microprocessor means (i) subjects the raw signal to a conversion step to convert said raw signal to an initial signal output which is indicative of the amount of analyte extracted by the sampling means, and (ii) performs a calibration step which correlates said initial signal output with a measurement value indicative of the concentration of analyte present in the biological system at the time of extraction. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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Specification