GLUCOSE DETECTOR AND METHOD FOR DIAGNOSING DIABETES

• US 20010023324A1
• Filed: 04/23/1999
• Published: 09/20/2001
• Est. Priority Date: 11/03/1997
• Status: Abandoned Application

• Current Assignee: Pacific Biometrics, Inc.
• Original Assignee: Pacific Biometrics, Inc.
• Inventors: BOOHER, JON, PRONOVOST, ALLAN
• Application Number:
  US09/298,398
• Publication Number:
  US 20010023324A1
• Time in Patent Office: Days
• US Class Current: 600/582
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

A non-invasive glucose monitoring device includes a mechanism for stimulating salivary glands secretion of saliva into oral fluid prior to collecting a sample of the oral fluid. A mechanism is provided for detecting the amount of glucose in the sample, a mechanism also being provided for quantitating blood glucose level based on the amount of glucose detected. A method of non-invasively monitoring glucose includes the steps of stimulating salivary glands secretion of saliva into oral fluid, collecting a sample of the oral fluid, detecting an amount of glucose in the sample, and then quantitating the blood glucose level based on the amount of glucose detected. These methods and devices are used to diagnosis individuals with glucose levels that indicate a diabetic disease state. The present invention is also usable to monitor the blood glucose levels of subjects who are being treated for diabetes.

Claims

1. A noninvasive method of diagnosing diabetes comprising:

stimulating salivary gland secretion of saliva into oral fluid;

measuring saliva glucose levels in a subject; and

diagnosing a diabetes disease state in said subject.

2. The method of

claim 1

, wherein the measuring step further comprises:

collecting a sample of oral fluid;

detecting an amount of glucose in the sample;

detecting an amount of glucose in the sample; and

quantitating a blood glucose level based on the amount of glucose detected.

3. The method of

claim 1

, wherein said measuring step comprises providing said subject a device for obtaining and measuring glucose levels in a saliva sample.

4. The method of

claim 3

, wherein said device comprises:

a stimulation means for stimulating salivary gland secretion of saliva into oral fluid;

collection means for collecting a sample of the oral fluid;

detection means operatively connected to said collection means for detecting an amount of glucose in the sample; and

quantitation means operatively connected to said detection means for quantitating blood glucose level based on the amount of glucose detected.

5. The method of

claim 4

, wherein the device further comprises a housing defining said collection means, said housing containing said stimulation means for release into a buccal cavity.

6. The method of

claim 1

, wherein said diagnosing step comprises reading a glucose level obtained from said subject and comparing said glucose level to a range of results, whereby said diagnosis of diabetes is made based upon said glucose level.

7. A noninvasive method of monitoring glucose levels comprising:

providing a subject being treated for diabetes;

stimulating salivary gland secretion of saliva into oral fluid;

measuring a saliva glucose level from said patient; and

determining a treatment course of action based on said saliva glucose level.

8. The method of

claim 7

, wherein said measuring step comprises:

providing said subject a device for collecting a sample of oral fluid;

detecting an amount of glucose in the sample; and

quantitating a blood glucose level based on the amount of glucose detected.

9. The method of

claim 8

, wherein said device comprises:

a stimulation means for stimulating salivary gland secretion of saliva into oral fluid;

collection means for collecting a sample of the oral fluid;

detection means operatively connected to said collection means for detecting an amount of glucose in the sample; and

quantitation means operatively connected to said detection means for quantitating blood glucose level based on the amount of glucose detected.

10. A method of monitoring blood glucose by:

stimulating salivary gland secretion of saliva into oral fluid;

collecting a sample of the oral fluid;

detecting an amount of glucose in the sample;

quantitating a blood glucose level based on the amount of glucose detected; and

determining a treatment action in view of the blood glucose level quantitated.