Chemical synthesis apparatus employing a droplet generator
First Claim
Patent Images
1. A chemical reaction apparatus comprising a. a reaction support having a plurality of reaction sites upon a first surface thereof;
- b. a first droplet generator for jetting first reactant droplets upon the first surface;
c. a second droplet generator for jetting second reactant droplets upon the first surface; and
d. control means for causing the droplets from each of the droplet generators, to impact upon preselected sets of said reaction sites.
0 Assignments
0 Petitions
Accused Products
Abstract
Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.
-
Citations
53 Claims
-
1. A chemical reaction apparatus comprising
a. a reaction support having a plurality of reaction sites upon a first surface thereof; -
b. a first droplet generator for jetting first reactant droplets upon the first surface;
c. a second droplet generator for jetting second reactant droplets upon the first surface; and
d. control means for causing the droplets from each of the droplet generators, to impact upon preselected sets of said reaction sites. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 25)
-
-
13. A chemical reaction apparatus comprising
a. a reaction support having a plurality of preselected reaction sites upon a first surface thereof; -
b. a droplet generator for jetting droplets of chemical reactant upon the first surface;
c. a plurality of reactant reservoirs in fluid communication with said droplet generator;
d. control means for causing chemical reactants from selected ones of said plurality of reactant reservoirs to be jetted by said droplet generator upon preselected sets of said reaction sites. - View Dependent Claims (14, 20, 21, 22, 23, 24)
-
-
26. A method for synthesizing a chemical species comprising
a. identifying a plurality of reaction sites upon a first surface of a reaction support; -
b. jetting upon a first set of said reaction sites, drops of fluid comprising a first chemical reactant species; and
c. jetting upon a second set of said reaction sites, drops of fluid comprising a second chemical reactant species. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
-
-
38. A method for synthesizing a chemical species comprising
a. bonding an initial reaction fragment to a first surface of a reaction support, said first surface having a plurality of preselected reaction sites; -
b. jetting upon a first set of said reaction sites a first chemical reactant species to effect a chemical reaction with the initial reaction fragment at the first set of reaction sites; and
c. jetting upon a second set of said reaction sites a second chemical reactant species to effect a chemical reaction with either i. the initial reaction fragment at sites not in common with said first set of reaction sites, or ii. the reaction product of the initial reaction fragment and the first chemical reactant at those sites which are in common with said first set of reaction sites. - View Dependent Claims (39, 40, 41, 42)
-
-
43. A chemical reaction assembly comprising a reaction support having first and second surfaces and being capable of transporting fluid contacting the first surface to the second surface of the support in a direction substantially normal to the first surface, and a collection plate adjacent to the second surface having a plurality of wells for receiving fluid transported through said support.
-
44. A chemical reaction apparatus comprising
a. a shaped body having first and second surfaces; -
b. said body having an array of reaction wells therein in fluid communication with each of said first and second surfaces; and
c. porous reaction support in said reaction wells. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51)
-
-
52. A method for chemical synthesis comprising
a. providing a reaction support having first and second surfaces; -
b. transporting to selected sites on the first surface of said reaction support a plurality of chemical reagents, the chemical nature, amount and sequence of which is predetermined and under the control of a control means to effect synthesis of a chemical species;
c. transporting said chemical species through the reaction support to the second surface thereof;
d. providing a collection plate having a plurality of collection wells adjacent to said second surface such that the chemical species is recovered in a well or wells. - View Dependent Claims (53)
-
Specification