Sustained release oxycodone formulations with no fed/fast effect
First Claim
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1. An oral solid sustained-release oral dosage form containing oxycodone which is bioavailable and does not exhibit a fed/fast effect, comprising an analgesically effective amount of oxycodone or a salt thereof;
- an effective amount of a sustained release carrier which preferentially causes said oxycodone to be released faster in simulated gastric fluid than in simulated intestinal fluid to provide analgesia for a time period from about 8 to about 24 hours when said dosage form is orally administered to a patient; and
optional pharmaceutical excipients.
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Abstract
A solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of oxycodone or a salt thereof together with a sustained release carrier which causes the formulation to preferentially release the drug in low pH (e.g., gastric fluid) is bioavailable and does not exhibit a fed/fast effect.
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Citations
7 Claims
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1. An oral solid sustained-release oral dosage form containing oxycodone which is bioavailable and does not exhibit a fed/fast effect, comprising
an analgesically effective amount of oxycodone or a salt thereof; an effective amount of a sustained release carrier which preferentially causes said oxycodone to be released faster in simulated gastric fluid than in simulated intestinal fluid to provide analgesia for a time period from about 8 to about 24 hours when said dosage form is orally administered to a patient; and
optional pharmaceutical excipients.- View Dependent Claims (2, 3, 4)
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5. A method for the preparation of an oral sustained release oxycodone formulation, the improvement comprising utilizing a sustained release carrier which preferentially releases oxycodone or a pharmaceutically acceptable salt thereof faster in simulated gastric fluid than in simulated intestinal fluid, such that the formulation is bioavailable and does not exhibit a fed/fast effect.
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6. A method of treating patients having moderate to severe pain, comprising administering an oral sustained-release formulation comprising effective amount of oxycodone or a pharmaceutically acceptable salt thereof in a sustained release carrier which preferentially releases oxycodone or a pharmaceutically acceptable salt thereof faster in simulated gastric fluid than in simulated intestinal fluid, such that the formulation is bioavailable and does not exhibit a fed/fast effect.
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7. A method of preparing an oral sustained-release oxycodone formulation which is bioavailable and which does not exhibit a fed/fast effect, comprising,
preparing a solid dosage form comprising an effective amount of oxycodone or a pharmaceutically acceptable salt thereof in a sustained release carrier which preferentially releases oxycodone or a pharmaceutically acceptable salt thereof faster in simulated gastric fluid than in simulated intestinal fluid, and optional pharmaceutical excipients, such that the formulation is bioavailable and does not exhibit a fed/fast effect.
Specification