Compositions and methods for prevention and treatment of chronic diseases and disorders including the complications of diabetes mellitus

• US 20010031744A1
• Filed: 04/05/2001
• Published: 10/18/2001
• Est. Priority Date: 02/04/1997
• Status: Abandoned Application

• Current Assignee: John V. Kosbab
• Original Assignee: John V. Kosbab
• Inventors: Kosbab, John V.
• Application Number:
  US09/827,251
• Publication Number:
  US 20010031744A1
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/15 Pinaceae (Pine family), e.g. pine or cedar
• CPC Class Codes: A61K 36/16 Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• CPC Class Codes: A61K 36/27 Asclepiadaceae (Milkweed family), e.g. hoya
• CPC Class Codes: A61K 36/45 Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/484 Glycyrrhiza (licorice)
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/87 Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: A61K 36/9068 Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/14 Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

This invention relates to nutrient and therapeutic compositions for treatment and prevention of symptoms and disease conditions associated with microangiopathy and macroangiopathy and to methods using the compositions. In particular, the invention relates to compositions useful in the treatment of diabetic retinopathy and nephropathy, to compositions useful in the treatment of other retinal disorders including macular degeneration and cataracts, to compositions useful in wound healing, to compositions useful for treatment and prevention of neuropathy, to compositions useful for treatment and prevention of cardiovascular disease and to compositions useful for the treatment and prevention of dental and periodontal disorders.

Claims

1. A composition for amelioration of the symptoms and conditions associated with microangiopathy or macroangiopathy which comprises:

(a) a plant extract having antioxidant effect comprising bioflavonoids in an amount effective for providing said antioxidant effect; and

(b) a neovascular regulator that is an inhibitor of angiogenesis.

2. The composition of

claim 1

wherein said neovascular regulator is chondroitin sulfate.

3. The composition of

claim 1

which comprises antioxidant bioflavonoid plant extracts from at least two different plant sources.

4. The composition of

claim 3

wherein said neovascular regulator is chondroitin sulfate and said composition further comprises a glucosamine.

5. The composition of

claim 4

which comprises Pine bark extract in an amount effective for providing an antioxidant effect.

6. The composition of

claim 1

for prevention and treatment of diabetic complications of microangiopathy which comprises:

(a) antioxidant components;

Pine bark extract;

Bilberry extract;

Tea polyphenols;

Vitamin C; and

Vitamin E.

in a combined amount effective for providing an antioxidant effect;

(b) Neovascular regulator components chondroitin sulphate and glucosamine sulphate in a combined amount effective for inhibiting angiogenesis and/or stabilization of the collagen matrix; and

(c) absorbable zinc and absorbable chromium in an amount effective for compensation of nutrient deficiency.

7. The composition of

claim 1

for prevention and treatment of diabetic complications of microangiopathy which comprises:

(a) antioxidant components;

a plant extract having antioxidant effect;

an antioxidant carotinoid;

an antioxidant flavonoid;

thiotic acid;

Vitamin C;

Vitamin E; and

Vitamin A

in a combined amount effective for providing an antioxidant effect and/or for stimulating collagen synthesis;

(b) neovascular regulators and/or factors for collagen synthesis;

chondroitin sulphate, and

glucosamine sulphate

in a combined amount effective for neovascular regulation and/or stimulating collagen synthesis;

(c) minerals;

absorbable zinc;

absorbable chromium;

absorbable magnesium; and

absorbable calcium

in an amount effective for compensating for nutritional deficiency.

8. The composition of

claim 7

further comprising:

Gymnema sylvestre;

Fenugreek seed; and

Ginkgo biloba

each present in an amount effective for providing therapeutic and/or protective function.

9. The composition of

claim 8

which comprises the components for formula IJ, each present in an amount effective for providing therapeutic and/or protective function.

10. The composition of

claim 1

for wound healing which comprises:

(a) a plant extract having antioxidant effect in an amount effective for providing an antioxidant effect;

(b)) chondroitin sulphate and glucosamine sulphate in a combined amount effective for providing for neovascular regulation and/or for promotion of collagen synthesis;

(c) absorbable magnesium in an amount effective for promotion of collagen synthesis.

11. The composition of

claim 10

which comprises:

Pine bark extract;

Grape seed extract;

Tea polyphenols;

chondroitin sulfate;

glucosamine sulfate;

Vitamin C;

absorbable magnesium

each component present in an amount effective for providing therapeutic or protective effect.

12. The composition of

claim 11

further comprising aloe vera in an amount effective for producing a benefit for wound healing.

13. The composition of

claim 12

further comprising:

Gymnema sylvestre;

Fenugreek seek;

thiotic acid; and

absorbable chromium

each in an amount effective for providing a therapeutic and/or protective effect.

14. A wound healing ointment comprising a composition of

claim 10

having the components:

a plant extract having antioxidant effect;

chondroitin sulphate;

Glucosamine sulphate; and

thiotic acid;

each in an amount effective for providing a therapeutic and/or protective effect in a carrier suitable for topical application.

15. The composition of

claim 10

which comprises the components of Formula IIG each present in an amount effective for providing a therapeutic and/or protective effect.

16. The composition of

claim 1

for treatment and/or prevention of neuropathy which comprises:

(a) a plant extract having antioxidant effect comprising bioflavonoids in an amount effective for providing an antioxidant effect;

(b) a neovascular regulator; and

(c) a source of glucosamine present in a combined amount effective for providing a therapeutic or protective effect.

17. The composition of

claim 16

which comprises:

Pine bark extract;

chondroitin sulphate;

glucosamine sulphate;

absorbable magnesium;

absorbable calcium;

thiotic acid;

Ginkgo biloba;

tea polyphenols;

Vitamin C; and

a source of essential fatty acids;

each component present in an amount effective for providing a therapeutic and/or protective effect.

18. The composition of

claim 17

further comprising:

Gymnema sylvestre;

Fenugreek seed; and

absorbable chromium.

19. The composition of

claim 18

formulated for topical application.

20. A composition according to

claim 1

for prevention and/or treatment of cardiovascular disease which comprises:

(a) a plant extract having antioxidant effect comprising bioflavonoids in an amount effective for providing an antioxidant effect;

(b) a neovascular regulator for providing for inhibition of angiogenesis and/or stimulation of collagen synthesis in an amount effective for providing a therapeutic and/or protective effect; and

(c) absorbable zinc present in an amount effective for compensating for nutrient deficiency.

21. The composition of

claim 20

which comprises:

Vitamin C;

Vitamin E;

Bilberry Extract;

Pine bark extract;

Tea polyphenols;

soy isolate;

chondroitin sulphate;

Glucosamine sulphate; and

absorbable zinc

each component present in an amount effective for providing a therapeutic and/or protective effect.

22. The composition of

claim 21

further comprising:

Gymnema sylvestre;

Fenugreek seed; and

absorbable chromium.

26. The composition of

claim 1

further comprising:

ginger;

allicin;

licorice extract;

each present in an amount effective for providing a therapeutic and/or protective effect.

27. A method for treating and/or preventing a symptom condition or disorder associated at least in part with microangiopathy and/or macroangiopathy in an individual having microangiopathy or macroangiopathy which comprises the step of administering to said individual the composition of

claim 1

.

28. A method for treating and/or preventing symptoms, conditions or disorders associated with diabetic microangiopathy in an individual having diabetic microangiopathy which comprises the step of administering to said individual the composition of

claim 6

.

29. A method for treatment of slow to heal or recurrent wounds in an individual having such wound which comprises the step of administering to said individual the composition of

claim 10

.

30. A method for treatment and/or prevention of cardiovascular disease in an individual having such disease or at risk of developing said disease which comprises the step of administering to said individual the composition of

claim 20

.

31. A method for treatment and/or prevention of neuropathy in an individual having said condition or at risk of developing said condition which comprises administering to said individual the composition of

claim 16

.

23. A composition for treatment and/or prevention of dental caries and periodontal disease which comprises:

(a) a plant extract having antioxidant effect in an amount effective for providing an antioxidant effect;

(b) absorbable calcium in an amount effective for compensation of nutrient deficiency; and

(c) a Vitamin D3 derivative or analog that induces substantially no hypercalcification in an amount effective for providing a therapeutic and/or protective effect.

24. The composition of

claim 23

which comprises:

Pine bark extract;

Tea polyphenols;

absorbable calcium; and

22-oxy-Vitamin D3

each component present in an amount effective for providing a therapeutic and/or protective effect.

25. The composition of

claim 24

further comprising:

Gymnema sylvestre;

Fenugreek seed; and

absorbable chromium.

32. A method for treatment and/or prevention of dental caries, periodontal disease and other gum disorders in an individual having such disease or condition which comprises the step of administering to said individual the composition of

claim 23

.