Mobility spectrometer
First Claim
Patent Images
1. An apparatus for separating and analyzing ions, comprising:
- an ionization source to generate ions, an ion drift cell coupled to said ionization source, in which the ions are separated according to their mobility and which comprises electrodes for transporting and focusing the ions, said focusing comprises a superposition of periodic field focusing and hyperbolic field focusing; and
, a detector coupled to said ion drift cell to detect the ions.
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Abstract
The present invention relates to an improved ion mobility spectrometer and method for the analysis of chemical samples. The improvements are realized in the optimization of resolution and sensitivity. Increases in sensitivity are realized by preserving a narrow spatial distribution of migrating ions through the use of periodic/hyperbolic field focusing. Additionally, novel combinations and configurations of components are used to simultaneously maintain a well defined ion packet and preserve sample throughput to the detector.
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Citations
108 Claims
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1. An apparatus for separating and analyzing ions, comprising:
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an ionization source to generate ions, an ion drift cell coupled to said ionization source, in which the ions are separated according to their mobility and which comprises electrodes for transporting and focusing the ions, said focusing comprises a superposition of periodic field focusing and hyperbolic field focusing; and
,a detector coupled to said ion drift cell to detect the ions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An apparatus for transporting ions, comprising:
an ion drift cell, which comprises electrodes for transporting and focusing the ions, said focusing consisting of a superposition of periodic field focusing and hyperbolic field focusing.
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36. An apparatus for transporting ions, comprising:
an ion drift cell, which comprises electrodes for transporting and focusing the ions, said focusing consisting of a combination of periodic field focusing and hyperbolic field focusing.
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37. An apparatus for separating and analyzing ions, comprising:
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an ionization source to generate ions, an ion drift cell coupled to said ionization source, in which the ions are separated according to their mobility and which comprises electrodes for focusing the ions, wherein said focusing comprises hyperbolic field focusing; and
,a detector coupled to said ion drift cell to detect the ions. - View Dependent Claims (38, 39)
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40. An apparatus for separating and analyzing ions, comprising:
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an ionization source to generate ions, an ion drift cell coupled to said ionization source, in which the ions are separated according to their mobility and which comprises electrodes for focusing the ions, said focusing consisting of a combination of periodic field focusing and hyperbolic field focusing; and
,a detector coupled to said ion drift cell to detect the ions. - View Dependent Claims (41)
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42. A method for separating and analyzing ions, comprising:
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generating ions from an ion source, separating ions in terms of their mobility wherein said step of separating comprises transporting the ions in a superposition of a periodic focusing field and a hyperbolic focusing field; and
,detecting said ions. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
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67. A method for separating and analyzing ions, comprising:
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generating ions from an ion source, separating ions in terms of their mobility wherein said step of separating comprises transporting the ions in a hyperbolic focusing field; and
,detecting said ions. - View Dependent Claims (68)
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69. A method for separating and analyzing ions, comprising:
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generating ions from an ion source, separating ions in terms of their mobility wherein said step of separating comprises transporting the ions in a combination of a periodic focusing field and a hyperbolic focusing field; and
,detecting said ions. - View Dependent Claims (70)
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71. An apparatus for performing ion mobility spectrometry comprising:
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an ionization source;
a drift cell to receive ions from said ionization source and having a parallel electrode assembly comprising components selected from the group consisting of at least one field correcting ring electrode and at least one movable cylindrical electrode; and
,an ion detector to receive and detect ions from said drift cell. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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84. An apparatus for performing ion mobility spectrometry comprising:
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an ionization source;
a drift cell to receive ions from said ionization source and having a parallel electrode assembly comprising at least one radius of curvature electrode; and
,an ion detector to receive and detect ions from said drift cell. - View Dependent Claims (85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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97. A method of collecting ion mobility spectrometric information comprising:
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generating a gaseous sample of ions using a technique selected from the group consisting of;
matrix assisted laser desorption ionization, electrospray ionization, laser ionization, photoionization, an electron ionization, chemical ionization, electric field ionization, surface ionization, radioactive ionization, discharge ionization; and
, multiphoton ionization,separating said gaseous sample of ions into packets of ions according to the ion mobilities of said packets through use of a drift cell having a parallel electrode assembly comprising components selected from the group consisting of at least one field correcting ring electrode and at least one movable cylindrical electrode; and
,detecting said ion packets. - View Dependent Claims (98, 99, 100, 101, 102)
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103. A method of collecting ion mobility spectrometric information comprising:
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generating a gaseous sample of ions using a technique selected from the group consisting of;
matrix assisted laser desorption ionization, electrospray ionization, laser ionization, photoionization, an electron ionization, chemical ionization, electric field ionization, surface ionization, radioactive ionization, discharge ionization; and
, multiphoton ionization,separating said gaseous sample of ions into packets of ions according to the ion mobilities of said packets through use of a drift cell having a parallel electrode assembly comprising at least one radius of curvature electrode; and
,detecting said ion packets. - View Dependent Claims (104, 105, 106, 107, 108)
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Specification