Method of managing pharmaceutical dosage

• US 20010039373A1
• Filed: 03/30/2001
• Published: 11/08/2001
• Est. Priority Date: 03/31/2000
• Status: Abandoned Application

• Current Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Original Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Inventors: Cunningham, Scott D., Dorsch, Robert R.
• Application Number:
  US09/823,529
• Publication Number:
  US 20010039373A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

A method is disclosed for the management of pharmaceutical dosage. The method involves transmitting medical data from a patient monitoring station via an electronic link to a centralized processing station where the data is analyzed and used to adjust pharmaceutical dosage which is provided to the patient in a personalized dosage delivery system. Optionally, analyzed data may be further enhanced at a data enhancement station where analyzed data from a multiplicity of central processing stations is accumulated and processed. Enhanced data may then be used to further refine the pharmaceutical dosage, alter the pharmaceutical being used, or develop new findings about the metabolic effects of the pharmaceutical.

Claims

1. A pharmaceutical monitoring and review system for transmitting medical data between a patient monitoring station and a central processing station and between the central processing station and one or more data enhancement stations over an integrated network the monitoring and review system comprising:

a) a patient monitoring station comprising a diagnostic means for measuring patient physiological condition in response to the presence of at least one pharmaceutical composition, the diagnostic means collecting and transmitting medical data via an electronic link means to a central processing station;

b) a central processing station for receiving medical data from the diagnostic means;

the central processing station comprising an algorithm for analysis of the medical data and a data storage unit for the storage and retrieval of medical data;

the central processing station transmitting the analyzed data to the patient monitoring station and optionally to at least one data enhancement station; and

c) a data enhancement station comprising at least one computer to receive the analyzed medical data from one or more central processing stations;

the computer comparing the analyzed medical data received from the one or more central processing stations with prior generated data to generate enhanced data.

2. A pharmaceutical monitoring and review system according to

claim 1

wherein the at least one pharmaceutical composition is contained in a personalized pharmaceutical delivery system.

3. A pharmaceutical monitoring and review system according to

claim 2

wherein the personalized pharmaceutical delivery system comprises:

a) a pharmaceutical; and

b) a non-toxic, biodegradable pharmaceutical delivery medium;

wherein the pharmaceutical is distributed uniformly within the pharmaceutical delivery medium such that division of the delivery medium according to unit length or unit area may be used to quantify the dosage of the pharmaceutical.

4. A pharmaceutical monitoring and review system according to

claim 1

wherein the physiological condition is characterized by measurements in a patient selected from the group consisting of levels of pharmaceutical, levels of pharmaceutical intermediates, levels of physiological metabolites, and nonchemical responses to the presence or absence of a pharmaceutical

5. A pharmaceutical monitoring and review system according to

claim 1

wherein the medical data is an alphanumeric or digital representation of the physiological condition.

6. A pharmaceutical monitoring and review system according to

claim 1

wherein the diagnostic means is selected from the group consisting of electronic biosensors, a clinical laboratory test and a home clinical test, the diagnostic means generating alphanumeric or digital medical data.

7. A pharmaceutical monitoring and review system according to

claim 1

wherein the electronic link means is selected from the group consisting of a fiberoptic cable and a radio signal.

8. A pharmaceutical monitoring and review system according to

claim 1

wherein the algorithm and the data storage unit are contained in a computer.

9. A pharmaceutical monitoring and review system according to

claim 1

wherein the pharmaceutical composition is packaged in discrete amounts.

10. A pharmaceutical monitoring and review system according to

claim 1

wherein enhanced data comprises medical data and analyzed data from a multiplicity of different centralized processing stations and patient monitoring means.

11. A method of monitoring and reviewing the administration of a pharmaceutical composition by operating a pharmaceutical monitoring and review system of

claim 1

comprising:

a) collecting medical data in a diagnostic means at the patient monitoring station, the data reflective of a patient'"'"'s physiological condition in response to the presence of at least one pharmaceutical composition;

b) transmitting the medical data from the diagnostic means via an electronic link means to a central processing station comprising an algorithm and a data storage unit for data analysis;

c) analyzing the medical data by the algorithm to generate analyzed data;

d) transmitting the analyzed data to least one computer located at a data enhancement station and to the patient monitoring station, whereby the dosage of the pharmaceutical composition is administered at the patient monitoring station;

e) collecting analyzed data from one or more central processing stations in the computer at the data enhancement station whereby enhanced data is generated; and

f) transmitting some or all of the enhanced data generated by the at least one computer to either or both of the patient monitoring station and the central processing station whereby dosage of the pharmaceutical composition is administered at the patient monitoring station.

12. A method according to

claim 11

wherein the at least one pharmaceutical composition is contained in a personalized pharmaceutical delivery system.

13. A method according to

claim 12

wherein the personalized pharmaceutical delivery system comprises:

a) a pharmaceutical; and

b) a non-toxic, biodegradable pharmaceutical delivery medium;

wherein the pharmaceutical is distributed uniformly within the pharmaceutical delivery medium such that division of the delivery medium according to unit length or unit area may be used to quantify the dosage of the pharmaceutical.

14. A method according to

claim 11

wherein the algorithm and the data storage unit are contained in a computer.

15. A method according to

claim 11

wherein after step (c) the analyzed data is converted to interpreted data.

16. A pharmaceutical management system for transmitting medical data between a patient monitoring station and a central processing station over an integrated network the management system comprising:

a) a patient monitoring station comprising a diagnostic means for measuring patient physiological condition in response to the presence of at least one pharmaceutical composition;

the composition contained in a personalized pharmaceutical delivery system, the diagnostic means collecting and transmitting medical data via an electronic link means to a central processing station;

b) a central processing station for receiving medical data from the diagnostic means;

the central processing station comprising an algorithm and a data storage unit for storage and analysis of the medical data;

the central processing station transmitting the analyzed medical data to the patient monitoring station whereby the at least one pharmaceutical composition is administered according to the personalized pharmaceutical delivery system.

17. A pharmaceutical management system according to

claim 16

wherein the personalized pharmaceutical delivery system comprises:

a) a pharmaceutical; and

b) a non-toxic, biodegradable pharmaceutical delivery medium;

wherein the pharmaceutical is distributed uniformly within the pharmaceutical delivery medium such that division of the delivery medium according to unit length or unit area may be used to quantify the dosage of the pharmaceutical.

18. A pharmaceutical management system according to

claim 16

wherein the physiological condition is characterized by measurements in a patient selected from the group consisting of levels of pharmaceutical, levels of pharmaceutical intermediates, levels of physiological metabolites, and non-chemical responses to the presence or absence of a pharmaceutical.

19. A pharmaceutical management system according to

claim 16

wherein the medical data is an alphanumeric or digital representation of the physiological condition.

20. A pharmaceutical management system according to

claim 16

wherein the diagnostic means is selected from the group consisting of electronic biosensors, a clinical laboratory test and a home clinical test, the diagnostic means generating alphanumeric or digital medical data.

21. A pharmaceutical management system according to

claim 16

wherein the diagnostic means is interfaced with the personalized pharmaceutical delivery system.

22. A pharmaceutical management system according to

claim 16

wherein the electronic link means is selected from the group consisting of a fiber-optic cable and a radio signal.

23. A pharmaceutical management system according to

claim 16

wherein the algorithm and the data storage unit are contained in a computer.

24. A pharmaceutical management system according to

claim 16

wherein the pharmaceutical composition is packaged in discrete amounts.

25. A method for managing pharmaceutical dosage of a pharmaceutical contained in a personalized pharmaceutical delivery system by operating the pharmaceutical management system of

claim 16

comprising:

a) collecting medical data in a diagnostic means at the patient monitoring station, the data reflective of a patient'"'"'s physiological condition in response to the presence of at least one pharmaceutical composition contained within a personalized pharmaceutical delivery system;

b) transmitting the medical data from the diagnostic means via an electronic link means to a central processing station comprising an algorithm and a data storage unit for data storage and analysis;

c) analyzing the medical data by the algorithm to generate analyzed data; and

d) transmitting the analyzed data to the patient monitoring station, whereby the dosage of the pharmaceutical composition is administered at the patient monitoring station according to the personalized pharmaceutical delivery system.

26. A method according to

claim 25

wherein the personalized pharmaceutical delivery system comprises:

a) a pharmaceutical; and

b) a non-toxic, biodegradable pharmaceutical delivery medium;

wherein the pharmaceutical is distributed uniformly within the pharmaceutical delivery medium such that division of the delivery medium according to unit length or unit area may be used to quantify the dosage of the pharmaceutical.

27. A method according to

claim 25

wherein the algorithm and the data storage unit are contained in a computer.

28. A method according to

claim 25

wherein the algorithm and the data storage unit are contained in a computer.

29. A method according to

claim 25

wherein the diagnostic means is interfaced with the personalized pharmaceutical delivery system.

30. A personalized pharmaceutical delivery system comprising:

a) a pharmaceutical; and

b) a non-toxic, biodegradable pharmaceutical delivery medium;

wherein the pharmaceutical is distributed uniformly within the pharmaceutical delivery medium such that division of the delivery medium according to unit length or unit area may be used to quantify the dosage of the pharmaceutical.

31. A pharmaceutical delivery system according to

claim 30

wherein the pharmaceutical delivery medium is in the form selected from the group consisting of a tube and a flat strip.