Reduction of inter-subject variation via transfer standardization

• US 20010039483A1
• Filed: 02/20/2001
• Published: 11/08/2001
• Est. Priority Date: 02/18/2000
• Status: Abandoned Application

• Current Assignee: Argose, Inc.
• Original Assignee: Argose, Inc.
• Inventors: Brand, Derek, Trepagnier, Pierre, Mansfield, James, Freeman, Jenny
• Application Number:
  US09/785,550
• Publication Number:
  US 20010039483A1
• Time in Patent Office: Days
• US Class Current: 702/104
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction

Abstract

This invention relates to the reduction of inter-subject variation via transfer standardization. According to the method, the effects of inter-subject variation on the analysis of spectra collected from the skin of two or more different subjects is reduced by correcting for the differences between spectra collected from said two or more subjects.

Claims

1. A method for reducing the effects of inter-subject variation on the analysis of spectra collected from the skin of two or more different subjects, comprising the step of

correcting for the differences between spectra collected from said two or more subjects.

2. The method of

claim 1

wherein the step of correcting comprises using an inter-subject transfer function.

3. The method of

claim 2

wherein the inter-subject transfer function comprises application of the following formula:

Spectrum_ABi=Spectrum_Ai×

[<

Spectrum_B>

/<

Spectrum_A>

],

wherein <

Spectrum_X>

is defined as the mean spectrum of X, and Spectrum A and Spectrum B are spectra of different individuals.

4. The method of

claim 1

wherein said inter-subject variation is caused by a difference in a skin parameter, between said subjects, selected from the group consisting of:

pigment content, hair content and color, roughness, moisture content, age, wrinkles, thickness, tanning, and any combination thereof.

5. An instrument for measuring an analyte level of a plurality of individuals comprising:

means for collecting spectra emitted from a first individual'"'"'s skin;

means for analyzing the collected spectra to determine the individual'"'"'s analyte level, said means for analyzing comprising means for correcting for variations in spectra among other individuals.

6. The instrument of

claim 5

wherein said analyte is glucose.