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Nonredundant split/pool synthesis of combinatorial libraries

  • US 20010041344A1
  • Filed: 02/02/2001
  • Published: 11/15/2001
  • Est. Priority Date: 02/03/2000
  • Status: Active Grant
First Claim
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1. A method of identifying selected members of a synthesized library of materials, comprising:

  • (a) providing at least n*m*f solid phase synthesis units, wherein n is equal to a number of choices of different first components in a first stage of synthesis, m is equal to a number of choices of different second components in a second stage of the synthesis, and f is equal to a number of solid phase synthesis units to comprise identical materials upon completion of the synthesis;

    (b) segregating the solid phase synthesis units into n separate first stage reaction vessels, wherein each separate first stage reaction vessel comprises at least m*f solid phase synthesis units;

    (c) reacting the solid phase synthesis units in each of the separate first stage reaction vessels with a different first component in the first stage of the synthesis;

    (d) segregating the solid phase synthesis units of (c) into m separate second stage reaction vessels by distributing at least one of the solid phase synthesis units from each of the separate first stage vessels into each separate second stage reaction vessel such that each of the separate second stage reaction vessels comprises at least n*f solid phase synthesis units;

    (e) reacting the solid phase synthesis units in each of the separate second stage reaction vessels with a different second component in the second stage of the synthesis, thereby synthesizing the library of the materials;

    (f) detecting one or more distinguishing physical properties of selected members of the library; and

    , (g) identifying the selected members based on the one or more detected distinguishing physical properties.

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